Ordering Recommendation

Not a standalone diagnostic test for ankylosing spondylitis. Use as an aid in the diagnosis of ankylosing spondylitis only if clinical signs and symptoms are present. This test should not be used for the prenatal diagnosis of ankylosing spondylitis because positive results do not predict the disorder.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or serum; collection of specimen in sodium heparin tubes. Frozen specimens in glass collection tubes.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month

Methodology

Polymerase Chain Reaction (PCR)/Fluorescence Monitoring

Performed

Sun-Sat

Reported

3-7 days

Reference Interval

By report

Interpretive Data

Refer to report.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

81374

Components

Component Test Code* Component Chart Name LOINC
3019467 Ankylosing Spondylitis (HLAB27) Specimen 31208-2
3019468 Ankylosing Spondylitis (HLA-B27) 26043-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • HLA-B27
  • HLA B27 genotyping
Ankylosing Spondylitis (HLA-B27) Genotyping