3019135
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High-Grade B-Cell Lymphoma Reflex Panel by FISH, Tissue

HGBCL RFLX

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UUHSC Testing Only

Ordering Recommendation

New York DOH Approval Status

This test is not New York state approved.

Specimen Required

Patient Preparation
Collect

Tumor tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin-embed specimen. Protect paraffin block from excessive heat. Transport tissue block or 8 unstained (3-micron thick sections) positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP ConnectTM or contact ARUP Client Services at 800-522-2787 (kit is recommended but not necessary). (Min: 4 slides)

Storage/Transport Temperature

Room temperature or refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.

Remarks

Include surgical pathology report. If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Methodology

Fluorescence in situ Hybridization (FISH)

Performed

Mon-Fri

Reported

3-7 days

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Analyte Specific Reagent (ASR)

Note

If Aggressive B-Cell Lymphoma Reflex Panel by FISH is positive, then IGH-BCL2 Fusion, t(14;18) by FISH (ARUP test code 3001298) and BCL6 (3q27) Gene Rearrangement by FISH (ARUP test code 3001311) will be added.
If Aggressive B-Cell Lymphoma Reflex Panel by FISH is negative, then 11q Aberrations by FISH (ARUP test code 3019126) will be added.
Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
10/20/2025
X
N/A

CPT Codes

88366; if reflexed, add 88366; 88377

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Components

Component Test Code* Component Chart Name LOINC
3000616 MYC FISH Reference Number
3000617 MYC FISH Source
3000618 MYC FISH Result
3000702 Total Cell Count 78236-7
3000703 Scoring Method 81304-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • High Grade B-Cell Lymphoma
  • High Grade B-Cell Lymphoma with 11q aberrations
  • HGBL-11q, HGBCL-11q
  • Burkitt Lymphoma
  • Burkitt-Like Lymphoma with 11q aberrations
  • BLL-11q
  • MLL (11q23) gain, FLI1 (11q.24.3) loss
  • MYC FISH
  • MYC gene rearrangement FISH
  • LSI MYC FISH
  • Double hit lymphoma, BCL2 FISH, BCL6 FISH
High-Grade B-Cell Lymphoma Reflex Panel by FISH, Tissue