3019126
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11Q Aberrations by FISH

11Q FISH

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UUHSC Testing Only

Ordering Recommendation

Facilitates diagnosis of high-grade B-cell lymphoma with 11q aberrations. Detects gain of MLL(KMT2A) in the 11q23 region and loss of FLI1 in the 11q24.3 region.

New York DOH Approval Status

This test is not New York state approved.

Specimen Required

Patient Preparation
Collect

Tumor tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin-embed specimen. Protect paraffin block from excessive heat. Transport tissue block or 6 unstained (3-micron thick sections) positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP ConnectTM or contact ARUP Client Services at 800-522-2787 (kit is recommended but not necessary). (Min: 3 slides)

Storage/Transport Temperature

Room temperature or refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.

Remarks

Include surgical pathology report. If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Methodology

Fluorescence in situ Hybridization (FISH)

Performed

Mon-Fri

Reported

3-7 days

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Analyte Specific Reagent (ASR)

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
10/20/2025
X
N/A

CPT Codes

88377

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Components

Component Test Code* Component Chart Name LOINC
3000703 Scoring Method 81304-8
3019127 11Q FISH Result 76065-2
3019129 MLL Total Cell Count 78234-2
3019130 FLI1 Total Cell Count
3019131 11Q FISH Reference Number 89873-4
3019132 11Q FISH Source 31208-2
3019133 MLL Percent Gain
3019134 FLI1 Percent Loss
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • HGBL-11q, HGBCL-11q, High Grade B-Cell Lymphoma with 11q aberrations, BLL-11q, Burkitt-Like Lymphoma with 11q aberrations, MLL (11q23) gain, FLI1 (11q.24.3) loss
11Q Aberrations by FISH