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Hepatitis B Virus Surface Antigen With Reflex to Confirmation and Reflex to Hepatitis Delta Virus Antibody by ELISA With Reflex to Hepatitis Delta Virus by Quantitative PCR

HBSAGRDABQ
Example Reports
Negative
Positive

Ordering Recommendation

Use to diagnose hepatitis D virus (HDV) infection in individuals with acute or chronic hepatitis B virus (HBV) infection. If the hepatitis B surface antigen (HBsAg) result is positive and confirmed, Hepatitis Delta Virus Antibody by ELISA With Reflex to Hepatitis Delta Virus by Quantitative PCR (3006379) will be added. If the HDV antibody result is positive, Hepatitis Delta Virus by Quantitative PCR (2013881) will be added. If HDV is positive by PCR, consider additional HBV IgM core antibody testing to determine whether HDV infection is a coinfection or a superinfection with HBV; refer to Hepatitis B Virus Core Antibody, IgM (0020092). 

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube (SST).

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 3 mL serum to an ARUP standard transport tube. (Min: 2 mL). This test requires a dedicated transport tube submitted only for HBSAGRDABQ testing. Separate specimens must be submitted when multiple tests are ordered.

Storage/Transport Temperature

Frozen

Unacceptable Conditions

Specimens containing particulate material or obvious microbial contamination. Heat-inactivated, severely hemolyzed, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 24 hours; Refrigerated: 5 days; Frozen: 4 months (avoid repeated freeze/thaw cycles)

Methodology

Qualitative Chemiluminescent Immunoassay (CLIA) / Qualitative Enzyme Immunoassay (EIA)

Performed

Varies

Reported

1-2 days

Reference Interval

Test Number
 Components
 Reference Interval
  Hepatitis B Surface Antigen Negative

Interpretive Data

This panel of assays should not be used for blood donor screening, associated reentry protocols, or for screening human cell, tissues, and cellular and tissue-based products (HCT/P).

Compliance Category

FDA

Note

Performed and Reported times indicated are for screening of the HBsAg. If results for HBsAg screen are repeatedly reactive with an index value between 1.00 and 50.00, then HBsAg Confirmation will be added.

If positive for hepatitis B surface antigen, Hepatitis Delta Virus Antibody by ELISA With Reflex to Hepatitis Delta Virus by Quantitative PCR (ARUP test code 3006379) will be added.

If the anti-HDV screening result is positive, Hepatitis Delta Virus by Quantitative PCR (ARUP test code 2013881) will be added. Performed and Reported times are for the antibody screening portion of this test. Refer to Hepatitis Delta Virus by Quantitative PCR regarding additional information regarding Performed and Reported times for the reflex portion of the test.

Additional charges apply each time a reflexive test is indicated and added.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
11/11/2024
X
N/A

CPT Codes

87340; if reflexed, add 87341; 86692; 87523

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Components

Component Test Code* Component Chart Name LOINC
0020089 Hepatitis B Surface Antigen 5196-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Chronic Hep Screen B
  • HBsAg
  • HBsAg screen
  • HBV Surface Antigen
  • HDV
  • HDV Ab
  • Hep B Surface Antigen
  • Hepatitis Bs Ag
  • Hepatitis D Virus
  • Hepatitis Delta Virus
Hepatitis B Virus Surface Antigen With Reflex to Confirmation and Reflex to Hepatitis Delta Virus Antibody by ELISA With Reflex to Hepatitis Delta Virus by Quantitative PCR