3017866
print

Dihydropyrimidine Dehydrogenase (DPYD) and UPD Glucuronosyltransferase 1A1 (UGT1A1) Genotyping

DPYDUGT1A1
Example Reports
Negative
Positive

Icon

Additional Technical Information

Icon

Informed Consent for Genetic Testing (Required for NY patients)

Icon

Supplemental Resources

Ordering Recommendation

Predicts risk of dose-related toxicity to 5-FU therapy. May be useful in dosage planning for individuals who will receive high-dose irinotecan, have personal or family history of sensitivity to irinotecan, or have experienced neutropenia while receiving irinotecan.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Two tubes of lavender (EDTA), pink (K2EDTA).

Specimen Preparation

Transport 3 mL whole blood in each tube. (Min: 1 mL in each tube)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Heparinized specimens. Frozen specimens in glass collection tubes.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week

Methodology

Polymerase Chain Reaction (PCR)/Fluorescence Monitoring/Fragment Analysis

Performed

Varies

Reported

5-10 days

Reference Interval

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/19/2024
X
N/A

CPT Codes

81232; 81350

Are you an ARUP Client? Click here for your pricing.

Components

Component Test Code* Component Chart Name LOINC
2013096 DPYD Genotype 45284-7
2013097 DPYD Phenotype 79719-1
3017865 DPYD Interpretation 79719-1
3017867 UGT1A1 Genotyping Specimen 66746-9
3017868 UGT1A1 Genotyping Allele 1 51951-2
3017869 UGT1A1 Genotyping Allele 2 51952-0
3017870 UGT1A1 Genotyping Interpretation 34509-0
3017872 EER DPYD UGT1A1 11526-1
3018244 DPYD Genotyping Specimen 31208-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 5FU drug toxicity
  • Dihydropyrimidine
  • DPD
  • DPYD
  • DPYD genotyping
  • Fegafur
  • Irinotecan Toxicity
  • Uftoral
  • UGT1A1
  • Xeloda
  • Capecitabine
Dihydropyrimidine Dehydrogenase (DPYD) and UPD Glucuronosyltransferase 1A1 (UGT1A1) Genotyping