Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG (CSF) With Reflex to Type 1 and 2 Glycoprotein G-Specific Ab, IgG
Ordering Recommendation
Not recommended for herpes simplex virus (HSV) testing; lacks adequate predictive value for acute infection. Preferred testing is Herpes Simplex Virus (HSV-1/HSV-2) Subtype by PCR (2010095).
New York DOH Approval Status
Specimen Required
CSF
Transfer 1 mL CSF to an ARUP standard transport tube. (Min: 0.5 mL)
Refrigerated.
Specimen types other than CSF. Contaminated, heat-inactivated, icteric, or hemolyzed specimens.
Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year
Methodology
Semi-Quantitative Chemiluminescent Immunoassay (CLIA) / Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)
Performed
Sun-Sat
Reported
1-2 days
Reference Interval
0.89 IV or less
Test Number |
Components |
Reference Interval |
---|---|---|
HSV 1/2 Antibody Screen IgG, CSF | 0.89 IV or less |
Interpretive Data
False positive results are possible. Consider additional testing for HSV-2, particularly if the result for HSV-2 is less than or equal to 3.0 IV.
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG, CSF | 0.89 IV or less: Negative. No significant level of detectable HSV IgG antibody. 0.90-1.09 IV: Equivocal. Questionable presence of IgG antibodies. Repeat testing in 10-14 days may be helpful. 1.10 IV or greater: Positive. IgG antibody to HSV detected which may indicate a current or past HSV infection. |
Laboratory Developed Test (LDT)
Note
If HSV 1/2 IgG, CSF is greater than or equal to 1.10 IV , then HSV 1 gG-specific IgG, CSF and HSV 2 gG-specific IgG, CSF will be added. Additional charges apply.
Hotline History
Hotline History
CPT Codes
86694; if reflexed, add 86695; 86696
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050394 | HSV 1/2 Antibody Screen IgG, CSF | 13249-8 |
Aliases
- HSV glycoprotein G-based type-specific CSF
- Herpes Simplex Antibodies, IgG CSF
- Herpes Simplex CSF
- HSV 1, 2 IgG CSF
- HSV 1,2
- glycoprotein type-specific reactivity
- HSV CSF antibody
- HSV glycoprotein G CSF
- HSV 1,2 glycoprotein CSF
- HSV 1,2 and glycoprotein reflex