3017747
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Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG (CSF) With Reflex to Type 1 and 2 Glycoprotein G-Specific Ab, IgG

HERPR CSF
Example Reports
Negative
Positive

Ordering Recommendation

Not recommended for herpes simplex virus (HSV) testing; lacks adequate predictive value for acute infection. Preferred testing is Herpes Simplex Virus (HSV-1/HSV-2) Subtype by PCR (2010095).

New York DOH Approval Status

This test is not New York state approved. There are no New York state-approved laboratories available and NYDOH is not accepting Non-permitted Laboratory Requests (NPL). Do not submit sample to ARUP.

Specimen Required

Patient Preparation
Collect

CSF

Specimen Preparation

Transfer 1 mL CSF to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Specimen types other than CSF. Contaminated, heat-inactivated, icteric, or hemolyzed specimens.

Remarks
Stability

Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 1 year

Methodology

Semi-Quantitative Chemiluminescent Immunoassay (CLIA) / Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Sun-Sat

Reported

1-2 days

Reference Interval

0.89 IV or less

Test Number
 Components
 Reference Interval
  HSV 1/2 Antibody Screen IgG, CSF 0.89 IV or less

Interpretive Data

False positive results are possible. Consider additional testing for HSV-2, particularly if the result for HSV-2 is less than or equal to 3.0 IV.


Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG, CSF 0.89 IV or less: Negative. No significant level of detectable HSV IgG antibody.
0.90-1.09 IV: Equivocal. Questionable presence of IgG antibodies. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Positive. IgG antibody to HSV detected which may indicate a current or past HSV infection.

Compliance Category

Laboratory Developed Test (LDT)

Note

If HSV 1/2 IgG, CSF is greater than or equal to 1.10 IV , then HSV 1 gG-specific IgG, CSF and HSV 2 gG-specific IgG, CSF will be added. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
07/21/2025
X
08/19/2024
X
N/A

CPT Codes

86694; if reflexed, add 86695; 86696

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Components

Component Test Code* Component Chart Name LOINC
0050394 HSV 1/2 Antibody Screen IgG, CSF 13249-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • HSV glycoprotein G-based type-specific CSF
  • Herpes Simplex Antibodies, IgG CSF
  • Herpes Simplex CSF
  • HSV 1, 2 IgG CSF
  • HSV 1,2
  • glycoprotein type-specific reactivity
  • HSV CSF antibody
  • HSV glycoprotein G CSF
  • HSV 1,2 glycoprotein CSF
  • HSV 1,2 and glycoprotein reflex
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG (CSF) With Reflex to Type 1 and 2 Glycoprotein G-Specific Ab, IgG