Ordering Recommendation

Use to identify TP53 mutations with prognostic and/or therapeutic significance in hematologic malignancies.

New York DOH Approval Status

Testing is not New York state approved. Specimens from New York clients will be sent out to a New York state-approved laboratory.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA), green (sodium heparin), bone marrow (EDTA), or bone marrow (sodium heparin).
New York State Clients: Lavender (EDTA) or pink (K2EDTA)

Specimen Preparation

Transport 3 mL whole blood or bone marrow. (Min: 1.5 for whole blood, 1.0 mL for bone marrow)
Separate specimens must be submitted when multiple tests are ordered.

New York State Clients: Transport 6 mL whole blood (Min: 3 mL) OR 3 mL bone marrow (Min: 1 mL). Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions

Serum, plasma, grossly hemolyzed specimens, buccal brush or swab, FFPE tissue.

Remarks

Specimen source is required.

Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Methodology

Qualitative Massively Parallel Sequencing

Performed

Varies

Reported

12-14 days

Reference Interval

Interpretive Data

Refer to report.

Compliance Category

Note

Gene tested: TP53 (NM_000546), all coding exons

Hotline History

N/A

CPT Codes

81351, 81352

Components

Component Test Code* Component Chart Name LOINC
3017692 TP53 WBBM Interp 103680-5
3019885 TP53 WBBM Specimen 66746-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Somatic TP53 Mutations in Whole Blood and Bone Marrow