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Vitamin C, Plasma (High-Dose Therapy)

VIT C IV

Ordering Recommendation

Use to assess elevated vitamin C concentrations associated with therapeutic intravenous infusion of vitamin C. 

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Green (sodium or lithium heparin). Place specimen in ice bath immediately. Also acceptable: Plasma separator tube.

Specimen Preparation

Protect from light, centrifuge, transfer plasma, and freeze within 1 hour of collection. Transfer 0.5 mL plasma to an ARUP amber transport tube. (Min: 0.3 mL)

Storage/Transport Temperature

CRITICAL FROZEN AND LIGHT PROTECTED. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

EDTA plasma, whole blood, or body fluids. Grossly hemolyzed specimens.

Remarks

Thawing and refreezing of the specimen and exposure to light will result in decreased vitamin C concentration.

Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month

Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun-Sat

Reported

1-6 days

Reference Interval

Test Number
 Components
 Reference Interval
  Vitamin C, Plasma 23-114 µmol/L

Interpretive Data

Intravenous vitamin C (IVC) administration produces millimolar plasma ascorbate (vitamin C) concentrations. Therapeutic concentrations average 15 mmol/L and range from 1-30 mmol/L. The maximum plasma concentration achieved by oral supplementation of vitamin C is approximately 250 µmol/L.

Vitamin C concentration is reported as micromoles per liter (µmol/L). To convert concentration to millimoles per liter (mmol/L), multiply the result by 0.001.

Compliance Category

Laboratory Developed Test (LDT)

Note

Thawing and refreezing of the specimen and exposure to light will result in decreased vitamin C concentration.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
05/03/2024
X
N/A

CPT Codes

82180

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Components

Component Test Code* Component Chart Name LOINC
0080380 Vitamin C, Plasma 1903-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Ascorbate
  • Intravenous Vitamin C
  • IVC
Vitamin C, Plasma (High-Dose Therapy)