TPSAB1 Copy Number Analysis by ddPCR

Use to assess TPSAB1 copy number variants in the diagnosis of hereditary alpha-tryptasemia (HaT). Consider in individuals with confirmed or suspected systemic mastocytosis or mast cell activation syndrome. Increased TPSAB1 copy number variants may also be associated with serum tryptase at or above 8 ng/mL, severe allergic reactions, recurrent anaphylaxis, skin flushing and pruritis, itching, Ehlers-Danlos syndrome or other connective tissue abnormalities, severe postural orthostatic tachycardia syndrome or other systemic venom reactions, gastroparesis, irritable bowel syndrome, dysautonomia, sleep disruption, and other systemic immediate hypersensitivity reactions.