Ordering Recommendation

Consider ordering for individuals with paraneoplastic encephalomyelitis, chorea, cerebellar degeneration, optic neuritis, and peripheral neuropathy. May aid in diagnosis of occult or recurrent tumor. Serum is the preferred specimen.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation


Specimen Preparation

Transfer 0.5 mL CSF to an ARUP standard transport tube. (Min: 0.15 mL)

Storage/Transport Temperature


Unacceptable Conditions

Hemolyzed, contaminated, or severely lipemic specimens.


Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month


Semi-Quantitative Cell-Based Indirect Fluorescent Antibody




1-8 days

Reference Interval

Test Number
Reference Interval
  CV2 Ab IgG CBA-IFA Screen, CSF Less than 1:1

Interpretive Data

CV2 antibodies aid in discriminating between chronic paraneoplastic neurological disorder (PND) and other inflammatory disorders of the nervous system. Anti-CV2 is associated with small-cell lung cancer and thymoma. A negative test result does not rule out a diagnosis of autoimmune neurologic disease. Results should be interpreted in correlation with the patient's clinical history and other laboratory findings.

This indirect fluorescent antibody assay utilizes CV2 transfected cell lines for the detection and semiquantification of the CV2 IgG antibody.

Compliance Category

Laboratory Developed Test (LDT)


If CV2 Antibody IgG Screen by IFA, CSF is positive, then CV2 Antibody IgG Titer, CSF will be added. Additional charges apply.

Hotline History


CPT Codes

86255; if reflexed, add 86256


Component Test Code* Component Chart Name LOINC
3002259 CV2 Ab IgG CBA-IFA Screen, CSF 53707-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Cerebellar degeneration
  • Chorea
  • Collapsin response-mediator protein 5
  • Cranial neuropathy
  • CRMP5
  • CV2
  • Myelopathy
  • Peripheral neuropathy
  • Vision loss
CV2 Antibody, IgG by CBA-IFA With Reflex to Titer, CSF