Ordering Recommendation

Adjunct test to aid in the diagnosis of histoplasmosis and blastomycosis. Test is not a substitute for culture and/or antigen testing.

New York DOH Approval Status

Testing is not New York state approved. Specimens from New York clients will be sent out to a New York state-approved laboratory.

Specimen Required

Patient Preparation

Bronchoalveolar lavage (BAL), sputum, or tissue

Specimen Preparation

Transfer 2 mL bronchoalveolar lavage (BAL) or sputum to a sterile container (min: 1.2 mL). Tissue: Transfer to a sterile container and freeze immediately.

Storage/Transport Temperature


Unacceptable Conditions

Formalin-fixed paraffin embedded tissue


Specimen source required


Ambient: Unacceptable; Refrigerated: 14 days; Frozen: 14 days


Qualitative Polymerase Chain Reaction (PCR)




1-3 days

Reference Interval

Interpretive Data

A negative result does not rule out the presence of PCR inhibitors in the patient specimen or test-specific nucleic acid in concentrations below the level of detection by the test.

Compliance Category

Laboratory Developed Test (LDT)


This test detects Histoplasma capsulatum and detects but does not differentiate Blastomyces dermatitidis and Blastomyces gilchristii.

Hotline History


CPT Codes

87798 x2


Component Test Code* Component Chart Name LOINC
3016796 Histoplasma, Blastomyces Source 31208-2
3016797 Histoplasma by PCR 95917-1
3016799 Blastomyces by PCR 95916-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Blastomyces dermatitidis
  • Blastomyces gilchristii
  • Histoplasma capsulatum
Histoplasma and Blastomyces by PCR