Ordering Recommendation

May aid in the diagnosis of bilateral rapidly progressive vision loss and suspected cancer-associated retinopathy. This test only evaluates for the presence of autoantibodies to recoverin. If a panel test is clinically indicated, consider ordering Autoimmune Vision Loss Panel, Serum (3016804) to assess for the presence of antibodies to recoverin and CV2/CRMP5.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.30 mL)

Storage/Transport Temperature


Unacceptable Conditions

Plasma. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.


After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month


Qualitative Immunoblot


Mon, Thu, Sat


1-4 days

Reference Interval

Test Number
Reference Interval
  Recoverin Ab, IgG by Immunoblot, Serum Negative

Interpretive Data

Antibodies to recoverin are found in a subset of patients with cancer-associated retinopathy. Symptoms of rapidly progressive bilateral vision loss may precede detection of cancer, and a positive test result should prompt a search for malignancy, most often small cell lung adenocarcinoma. A negative test result does not rule out the diagnosis of autoimmune vision loss. Results should be interpreted in the context of the patient's clinical history, neurologic and ophthalmologic exam, and other laboratory findings.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
3016805 Recoverin Ab, IgG by Immunoblot, Serum 83003-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Cancer associated retinopathy
  • CAR
  • Optic neuropathy
  • Recoverin
  • Vision loss
Recoverin Antibody, IgG by Immunoblot, Serum