Ordering Recommendation

Useful to diagnose primary membranous nephropathy (PMN) and distinguish from secondary nephrotic syndrome. Semiquantitative measurement of PLA2R antibody levels by ELISA is suggested to monitor response over time in individuals undergoing treatment for membranous nephropathy.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Separate serum from cells ASAP or within 2 hours of collection.


Serum separator tube.

Specimen Preparation

Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Contaminated, heat-inactivated, grossly hemolyzed, grossly icteric, or grossly lipemic specimens.


After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 2 weeks


Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)


Mon, Wed, Thu, Fri


1-4 days

Reference Interval

Test Number
Reference Interval
  Anti-Phospholipase A2 Receptor, IgG < 14 RU/mL

Interpretive Data

A positive anti-phospholipase A2 receptor (PLA2R) antibody result by ELISA or IFA in conjunction with clinical symptoms and other laboratory findings is suggestive of primary membranous nephropathy (pMN). Absence of circulating anti-PLA2R receptor autoantibodies does not rule out a diagnosis of pMN. Anti-PLA2R antibody titers, due to its high predictive value, can be useful for assessing disease severity and monitoring clinical remission. In patients with pMN undergoing treatment, low antibody titers are associated with disease remission and high titers indicate loss of kidney function and need for an aggressive therapeutic approach.

Interpretive Data
Anti-Phospholipase A2 Receptor, IgG Negative:       Less than 14 RU/mL
Borderline:     14-19 RU/mL
Positive:         Greater than or equal to 20 RU/mL

Compliance Category



Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
3016768 Anti-Phospholipase A2 Receptor, IgG 73737-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • PLA2R
Anti-Phospholipase A2 Receptor (PLA2R) Antibody, IgG by ELISA