Ordering Recommendation

Fetal RhE/e genotyping to assess risk for alloimmune hemolytic disease. For parental or neonatal testing, refer to RhE/e (RHCE) Antigen Genotyping (3002003).


Polymerase Chain Reaction (PCR)/Fluorescence Monitoring/Fragment Analysis




3-10 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation

Fetal genotyping: Amniotic fluid.
Cultured amniocytes: Two T-25 flasks at 80 percent confluency.
If the client is unable to culture, order test Cytogenetics Grow and Send (ARUP test code 0040182) in addition to this test and ARUP will culture upon receipt (culturing fees will apply). If you have any questions, contact ARUP's Genetics Processing at 800-522-2787 ext. 3301.
AND maternal cell contamination specimen (see Note): Lavender (K2EDTA), pink (K2EDTA), or yellow (ACD solution A or B).

Specimen Preparation

Amniotic fluid: Transport 10 mL amniotic fluid in a sterile container. (Min: 5 mL).
Cultured amniocytes: Transport two T-25 flasks at 80 percent confluency filled with culture media. Backup cultures must be retained at the client's institution until testing is complete.
Maternal cell contamination specimen: Transport 3 mL whole blood (Min: 1 mL)
Whole blood (parental genotyping): Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Amniotic fluid, cultured amniocytes: CRITICAL ROOM TEMPERATURE. Must be received within 48 hours of shipment due to lability of cells.
Whole blood or maternal cell contamination specimen: Refrigerated.

Unacceptable Conditions

Plasma or serum. Specimens collected in sodium heparin tubes. Frozen specimens in glass collection tubes.


Patient History Form is available on the ARUP Web site or by contacting ARUP Client Services.


Fetal specimens: Ambient: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable
Whole blood or maternal cell contamination specimen: Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month

Reference Interval

By report

Interpretive Data

Refer to report.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Compliance Category

Modified FDA


Maternal specimen is recommended for proper test interpretation; order Maternal Cell Contamination, Maternal Specimen.

Hotline History


CPT Codes

0001U; 81265 Fetal Cell Contamination (FCC)


Component Test Code* Component Chart Name LOINC
0050548 Maternal Contamination Study Fetal Spec 59266-7
0050612 Maternal Contam Study, Maternal Spec 66746-9
3016683 RHE GENO, Fetal Specimen 31208-2
3016684 RhEe Genotype Fetal, Interp 48030-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • RHCE genotyping
RhE/e (RHCE) Antigen Genotyping, Fetal