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Acute Myeloid Leukemia Panel by FISH

FISHAML
Example Reports
Abnormal
Enhanced Report
Normal

Ordering Recommendation

Use to identify cytogenetic abnormalities with diagnostic and prognostic significance in suspected or newly diagnosed acute myeloid leukemia (AML). To monitor therapeutic response using specific probes, refer to Chromosome FISH, Interphase (2002298).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Nondiluted bone marrow aspirate collected in a heparinized syringe. Also acceptable: Whole blood in green (sodium heparin). Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions.

Specimen Preparation

Transfer bone marrow to a green (sodium heparin). Transport 3 mL bone marrow. (Min: 1 mL) OR Transport 5 mL whole blood. (Min: 2 mL)

Storage/Transport Temperature

Room temperature

Unacceptable Conditions

Clotted or paraffin-embedded specimens.

Remarks
Stability

Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable

Methodology

Fluorescence in situ Hybridization (FISH)

Performed

Sun-Sat

Reported

3-10 days

Reference Interval

Normal

Interpretive Data

Probes included: RPN1/MECOM (EVI1), EGR1, D7S486, RUNX1T1/RUNX1, KMT2A (MLL), CBFB/MYH11, and NUP98. The probe for PML/RARa; is added automatically and is performed along with the panel. However, due to the longer turnaround time required for the panel, the result of this probe is reported as soon as available and is charged separately. (See PML-RARA Translocation by FISH, ARUP test code 2002363.)

Compliance Category

Laboratory Developed Test (LDT)

Note

If cell pellets or dropped cytogenetic slides are submitted, processing fee will not apply.
Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions.

A processing fee will be charged if this procedure is canceled, at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth. The fee will vary based on specimen type.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/21/2023
X
N/A

CPT Codes

88271 x7; 88275 x7

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Components

Component Test Code* Component Chart Name LOINC
2002385 FISH AML Panel
3016667 EER AML Panel by FISH
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • acute myelogenous leukemia
  • AML Panel
  • FISH
  • Fluorescence in situ hybridization
  • myelogenous leukemia
  • oncology FISH probes
  • t(15;17)
Acute Myeloid Leukemia Panel by FISH