Ordering Recommendation

Aids in the workup of suspected rheumatoid arthritis or undifferentiated inflammatory arthritides. If anticyclic citrullinated peptide (anti-CCP) IgG or rheumatoid factor is positive, rheumatoid factors IgA, IgG, and IgM will be performed to aid in prognosis. The preferred test for initial workup is Rheumatoid Arthritis (RA) Panel (3016634).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Fasting specimen preferred.


Serum separator tube (SST).

Specimen Preparation

Allow serum to clot completely at room temperature before centrifuging. Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.8 mL) Serum is the only acceptable specimen type for this test without a disclaimer.

Storage/Transport Temperature


Unacceptable Conditions

Contaminated, heat-inactivated, hemolyzed, icteric, or severely lipemic specimens.


After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (should not be thawed more than once)


Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)/Quantitative Immunoturbidimetry




1-4 days

Reference Interval

Test Number
Reference Interval
  Rheumatoid Factor 0-14 IU/mL
  Carbamylated Protein Antibody, IgG 0-19 Units
  Cyclic Citrullinated Peptide Ab, IgG/A 19 Units or less

Interpretive Data

Refer to report.

Compliance Category

Analyte Specific Reagent (ASR)


If CCP IgG/IGA is 20 units or greater and/or rheumatoid factor is 15 IU/mL or greater, then Rheumatoid Factor, IgA, IgM, and IgM by EIA will be performed. Additional charges apply.

Hotline History


CPT Codes

86200; 86431; 83516 if reflexed, add 83516 x3


Component Test Code* Component Chart Name LOINC
0050465 Rheumatoid Factor 11572-5
3003993 Carbamylated Protein Antibody, IgG
3016633 Cyclic Citrullinated Peptide Ab, IgG/A 57093-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Carbamylated Protein IgG
  • CarP IgG
  • CCP and RF IgA IgG IgM
  • CCP, RF, RF isotypes
  • RA
  • RA panel reflex RF
  • RF
Rheumatoid Arthritis (RA) Panel with Reflex to Rheumatoid Factors, IgA, IgG, and IgM by ELISA