Hemoglobin S Evaluation with Reflex to RBC Solubility
Use to determine the presence of hemoglobin S. Recommended test to detect sickle cell trait in athletes.
High Performance Liquid Chromatography (HPLC)/RBC Solubility
New York DOH Approval Status
Lavender (EDTA) or pink (K2EDTA).
Transport 5 mL whole blood. (Min: 0.2 mL)
Frozen or room temperature specimens.
Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Unacceptable
Negative: Negative for Hemoglobin S by HPLC. Solubility testing not performed.
Positive: Positive for Hemoglobin S by HPLC and confirmed by solubility testing. Additional charges apply.
Conf Previous: Positive for Hemoglobin S by HPLC. Solubility testing performed previously and not repeated with this submission.
This test does not differentiate hemoglobin S trait from homozygous sickle cell disease or other possible combinations such as: S/C, S/D, S/G, S/E, S/thalassemia, S/O-Arab, S/New York and C-Georgetown trait (Hb C-Harlem). For further clarification, Hemoglobin Evaluation with Reflex to Electrophoresis and/or RBC Solubility (ARUP test code 0050610) is recommended.
If HPLC detects a peak which suggests Hgb S, then RBC Solubility will be added for confirmation. Additional charges apply.
83021; if reflexed, add 85660
|Component Test Code*||Component Chart Name||LOINC|
|3016617||Hemoglobin S Evaluation||4621-9|
- Hb S
- Hgb S
- Sickle Cell Anemia Screen
- Sickle Cell Disease