Ordering Recommendation

Use to detect Mycoplasmoides (Mycoplasma) genitalium and predict resistance to macrolide antibiotics.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Genital swab, rectal swab, or urine.

Specimen Preparation

Transfer swab or 1 mL urine to viral transport media (ARUP supply #12884) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at 800-522-2787.
Neat urine: Transfer 1mL of urine to sterile container. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Specimen source required


Ambient: 48 hours; Refrigerated: 10 days; Frozen: 14 days


Qualitative Polymerase Chain Reaction (PCR)


Sun, Wed


2-7 days

Reference Interval

Interpretive Data

Macrolide drug resistance is predicted based on melt probe analysis. Common resistance associated mutations occur at positions A2058, A2059, and A2062 (E. coli numbering) of the 23S rRNA gene. Other mutations of unknown significance may be detected by this assay, however this was not observed in samples sequenced during assay development and validation. This test is intended for use in conjunction with clinical presentation.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes

87798, 87563


Component Test Code* Component Chart Name LOINC
3006345 M. genitalium source
3006346 M. genitalium by PCR
3006347 Macrolide Resistance by PCR
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Azithromycin drug resistance
  • drug resistance
  • M. genitalium
  • Macrolide
  • Mycoplasma
  • Mycoplasma genitalium
Mycoplasmoides genitalium Detection and Macrolide Resistance by PCR