Helicobacter pylori, Breath Test

3006271
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Positive

Ordering Recommendation

Aids in the initial diagnosis and posttreatment monitoring of Helicobacter pylori infection in adult patients and in pediatric patients 3-17 years of age.

Posttreatment monitoring of H. pylori should be performed no sooner than 6 weeks after treatment for H. pylori infection. Earlier assessment may give false results.

Mnemonic

HPBT

Methodology

Qualitative Spectrophotometry

Performed

Sun-Sat

Reported

1-4 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Remind the patient that there is 84 mg of phenylalanine per packet of Citrica Powder. Phenylketonurics restrict dietary phenylalanine.
The patient should have fasted at least one hour before administering the solution. The patient should not have taken antimicrobials, proton pump inhibitors (e.g., Prilosec, Prevacid, Aciphex, Nexium), or bismuth preparations (e.g., Pepto Bismol) within two weeks prior to administering the test.

Collect

Breath Test Kit IDkit Hp (TM) Two (ARUP Supply #58132) available online through e-Supply using ARUP Connect (TM) or contact ARUP Client Services at 800-522-5787.

Specimen Preparation

1) Label breath collection bags with patient name, MRN, date and time of collection, and indicate Baseline (blue) or Post Ingestion (gray).
2) Collect the blue Baseline specimen according to the instructions in the Breath Test Kit, IDkit Hp (TM) Two. Instruct the patient to hold their breath for 4-5 seconds, and then exhale into the blue Baseline collection bag until the bag is full.
3) Prepare the test drink per kit instructions.
4) Administer the test drink within two hours of preparation per kit instructions and precautions. Regardless of age and bodyweight, the patient must consume the entire solution through the provided straw within 2 minutes.
5) Collect the gray Post Ingestion specimen 15 minutes after ingestion of the test drink, but no later than 20 minutes post ingestion. Instruct the patient to hold their breath for 4-5 seconds, and then exhale into the gray Post Ingestion collection bag until the bag is full.
6) Ensure the caps on the bag mouthpieces are secured (push until they click).

Storage/Transport Temperature

CRITICAL ROOM TEMPERATURE. Do not freeze. Protect bags from sharp objects and direct sunlight. Refrain from applying any external pressure on the Breath Sample Bags.

Unacceptable Conditions

Underinflated or uncapped bags. Specimens from patients younger than 3 years.

Remarks

Also Acceptable: BreathTek UBT Kit. Follow collection instructions included in kit. The patient should be informed that the Pranactin-Citric drink that will be administered contains phenylalanine. Phenylketonurics restrict dietary phenylalanine.

Submit with order for BreathTek UBT Kit specimens of patients 3-17 years of age: Weight (in pounds), height (in inches), sex, and age.

1) Label breath collection bags with patient name, MRN, date and time of collection, and indicate Baseline (blue) or Post-dose (pink).
2) Collect the blue Baseline specimen according to the instructions in the BreathTek UBT kit.
3) After the allotted time, collect the pink Post-dose specimen according to the instructions in the kit.
4) Ensure the caps on the bag mouthpieces are secured (push until they snap).

Stability

Ambient: 2 weeks; Refrigerated: Unacceptable; Frozen: Unacceptable.

Reference Interval

Negative

Interpretive Data

A negative result does not rule out the possibility of Helicobacter pylori infection.  If clinical signs are suggestive of H. pylori infection, retest with a new specimen or an alternate method.

Known causes of false-negative results include:

1. Ingestion of antimicrobials, proton pump inhibitors, and bismuth preparations during the preceding 2 weeks.

2. Administration of the breath test less than 4 weeks after completion of definitive therapy to eradicate H. pylori.

3. Premature or late collection of the postdose specimen.

Known causes of false-positive results include:

1. Patients with achlorhydria.

2. Rinsing the testing solution in the mouth or not using the straw provided in the kit, which can allow contact with urease-positive bacteria.

3. The presence of other gastric spiral organisms such as Helicobacter heilmannii.

Compliance Category

FDA

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
04/03/2023
X
N/A

CPT Codes

83013

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Components

Component Test Code* Component Chart Name LOINC
3006272 H. pylori, Breath Test 29891-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 13C Urea Breath Test
  • BreathID
  • H pylori
  • H. pylori Urea Breath Test
  • Helicobactor
  • Helicobactor pylori Breath Test
  • Pylori
  • UBIT
  • UBT
  • Ulcer Breath Test
  • Urea Breath Test
Helicobacter pylori, Breath Test