Ordering Recommendation

Qualitative test to detect antibodies to John Cunningham (JC) virus. Aids in risk stratification for the development of progressive multifocal leukoencephalopathy (PML) in individuals with multiple sclerosis or Crohn’s disease who are receiving natalizumab therapy.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Plain red or serum separator tube (SST). Also acceptable: Lavender (K2EDTA)

Specimen Preparation

Transfer 1 mL serum or plasma to an ARUP standard transport tube. (Min: 0.5 mL)
Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.

Storage/Transport Temperature

Refrigerated. Also acceptable: Room temperature or frozen.

Unacceptable Conditions

Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 months


Enzyme-Linked Immunosorbent Assay (ELISA)




3-7 days

Reference Interval

By report

Interpretive Data

Compliance Category

Performed by non-ARUP Laboratory


If antibody result is indeterminate, then a confirmation (inhibition) assay will be added.

Hotline History


CPT Codes

86711; if reflexed, add 86711


Component Test Code* Component Chart Name LOINC
3006255 JC Virus Index 100977-8
3006256 JC Virus Antibody 70173-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • JC polyoma virus
  • John Cunningham virus
  • natalizumab
  • progressive multifocal leukoencephalopathy (PML)
  • Stratify JCV Antibody with Index
JC Virus Antibody by ELISA, Serum with Reflex to Inhibition Assay

Quest Diagnostics San Juan Capistrano Inc.