3006207
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Autoimmune Movement Disorder Panel, CSF

AIMDC
Example Reports
Negative
Positive

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Additional Technical Information

Ordering Recommendation

Use to evaluate subacute-onset movement disorders. If new-onset epilepsy is the prominent feature, refer to Autoimmune Epilepsy Panel, CSF (3006205). For individuals who present specifically with stiffness, spasms, hyperekplexia, limb rigidity, or limb dystonia, refer to Autoimmune Stiff-Person Disorders, CSF (3006235). For testing in individuals <18 years of age, refer to Autoimmune Pediatric CNS Disorders, CSF (3006211).

Testing in both serum and CSF is recommended to maximize diagnostic yield; refer to Autoimmune Movement Disorder Panel, Serum (3006206) for serum testing.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

N/A

Collect

CSF

Specimen Preparation

Transfer three 1 mL CSF aliquots to ARUP standard transport tubes. (Min: 0.5 mL/aliquot)

Storage/Transport Temperature

Frozen

Unacceptable Conditions

Fluid other than CSF. Grossly hemolyzed specimens

Remarks
Stability

After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (avoid repeated freeze/thaw cycles)

Methodology

Semi-Quantitative Cell-Based Indirect Fluorescent Antibody/Semi-Quantitative Indirect Fluorescent Antibody (IFA)/Qualitative Immunoblot/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Varies

Reported

3-10 days

Reference Interval

Test Number
 Components
 Reference Interval
  mGluR1 Ab IgG CBA-IFA Screen, CSF Less than 1:1
  Glutamic Acid Decarboxylase Antibody CSF 0.0-5.0 IU/mL
  LGI1 Ab IgG CBA-IFA Screen, CSF Less than 1:1
  NMDA Receptor Ab IgG CBA-IFA, CSF Less than 1:1
  CASPR2 Ab IgG CBA-IFA Screen, CSF Less than 1:1
  AMPA Receptor Ab IgG CBA-IFA Screen, CSF Less than 1:1
  GABA-BR Ab IgG CBA-IFA Screen, CSF Less than 1:1
  CV2 Ab IgG CBA-IFA Screen, CSF Less than 1:1
  DPPX Ab IgG CBA-IFA Screen, CSF Less than 1:1
  IgLON5 Ab IgG CBA-IFA Screen, CSF Less than 1:1
  SOX1 Antibody, IgG by Immunoblot, CSF Negative
  Amphiphysin Antibody, CSF Negative
  GABA-AR Ab IgG CBA-IFA Screen, CSF Less than 1:1
  ITPR1 Ab IgG CBA-IFA Screen, CSF Less than 1:1
  Paraneoplastic Abs (PCCA/ANNA) IgG, CSF None Detected

Interpretive Data

Refer to report

Compliance Category

Laboratory Developed Test (LDT)

Note

If NMDA CSF antibody IgG is positive, then titer will be performed. Additional charges apply.
If CV2 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
PCCA/ANNA CSF antibody IgG is screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be performed. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot will be performed. Additional charges apply.
If LGI1 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If CASPR2 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If DPPX CSF antibody IgG by IFA is positive, then titer will be added. Additional charges apply.
If AMPA CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-BR CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-AR CSF antibody IgG by IFA is positive, then titer will be added. Additional charges apply.
If mGluR1 CSF antibody IgG by IFA is positive, then titer will be added. Additional charges apply.
If ITPR1 CSF antibody IgG by IFA is positive, then titer will be added. Additional charges apply.
If IgLON5 CSF antibody IgG by IFA is positive, then titer will be added. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/20/2024
X
X
X
05/15/2023
X
N/A

CPT Codes

86341; 84182 x2; 86255 x12; if reflexed add 84182 x4; 86256 per titer

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Components

Component Test Code* Component Chart Name LOINC
2005165 NMDA Receptor Ab IgG CBA-IFA, CSF 80220-7
2010842 Paraneoplastic Abs (PCCA/ANNA) IgG, CSF 14247-1
3001258 AMPA Receptor Ab IgG CBA-IFA Screen, CSF 82732-9
3001268 GABA-BR Ab IgG CBA-IFA Screen, CSF 82984-6
3001987 CASPR2 Ab IgG CBA-IFA Screen, CSF 90820-2
3001991 LGI1 Ab IgG CBA-IFA Screen, CSF 90830-1
3002259 CV2 Ab IgG CBA-IFA Screen, CSF 53707-6
3002789 Glutamic Acid Decarboxylase Antibody CSF 42501-7
3002904 SOX1 Antibody, IgG by Immunoblot, CSF 94383-7
3004511 Amphiphysin Antibody, CSF 57750-2
3004513 DPPX Ab IgG CBA-IFA Screen, CSF 94283-9
3006004 GABA-AR Ab IgG CBA-IFA Screen, CSF
3006014 IgLON5 Ab IgG CBA-IFA Screen, CSF 96481-7
3006024 ITPR1 Ab IgG CBA-IFA Screen, CSF 96468-4
3006040 mGluR1 Ab IgG CBA-IFA Screen, CSF 93500-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • AGNA
  • AMPA
  • AMPA-R
  • Amphiphysin
  • ANNA
  • Anti-glial nuclear antibody
  • Anti-neuronal nuclear antibody
  • Ataxia
  • Brainstem encephalitis
  • CASPR2
  • Chorea
  • Contactin-associated protein-like-2
  • CRMP-5
  • CV2
  • Dipeptidyl aminopeptidase-like protein 6
  • DPPX
  • Dyskinesias
  • dystonia
  • GABA-B
  • GABA-BR
  • GAD65
  • Glutamic acid decarboxylase
  • IgLON5
  • ITPR1
  • Leucine-rich glioma inactivated protein-1
  • LGI1
  • metabotropic glutamate receptor 1
  • mGluR1
  • Movement disorder
  • Myoclonus
  • NMDA
  • NMDA-R
  • Parkinsonism
  • PCA
  • PCCA
  • Purkinje cell cytoplasmic antibody
  • rigidity
Autoimmune Movement Disorder Panel, CSF