Muscle-Specific Kinase (MuSK) Antibody, IgG by CBA-IFA with Reflex to Titer, Serum
Secondary test for the diagnosis of generalized or ocular myasthenia gravis in patients with no detectable acetylcholine receptor (AChR) antibodies.
Semi-Quantitative Cell-Based Indirect Fluorescent Antibody
Mon, Wed, Fri
New York DOH Approval Status
One 4 mL plain red or serum separator tube (SST)
Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL of serum to an ARUP standard transport tube. (Min: 0.5 mL)
Grossly lipemic, icteric, or hemolyzed specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month (avoid multiple freeze/thaw cycles)
|MuSK Ab IgG CBA IFA Screen, Serum||Less than 1:10|
Muscle-specific kinase (MuSK) antibody is found in a subset of patients with myasthenia gravis, primarily those seronegative for muscle acetylcholine receptor (AChR) antibody. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of myasthenia gravis.
This indirect fluorescent antibody cell-based assay (CBA) utilizes muscle-specific kinase (MuSK) transfected cells for the detection of the MuSK IgG antibody.
Laboratory Developed Test (LDT)
If MuSK SER antibody IgG is positive, then titer will be added. Additional charges apply.
86255; if reflexed add 86256
|Component Test Code*||Component Chart Name||LOINC|
|3006252||MuSK Ab IgG CBA IFA Screen, Serum||38362-0|
- Muscle-Specific Kinase
- Muscle-Specific Kinase Antibody by CBA
- Muscle-Specific Receptor Tyrosine Kinase
- MuSK Autoantibody
- Myasthenia Gravis
- Seronegative Myasthenia Gravis