Autoimmune Neurologic Disease Panel With Reflex, CSF

3006052
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Ordering Recommendation

Comprehensive panel for the evaluation of paraneoplastic disorders and/or encephalitis in the presence or absence of malignancy.

Mnemonic

NEURORCSF2

Methodology

Semiquantitative Cell-Based Indirect Fluorescent Antibody/Qualitative Immunoblot/Quantitative Radioimmunoassay/Semiquantitative Enzyme-Linked Immunosorbent Assay

Performed

Tue

Reported

3-10 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

CSF

Specimen Preparation

Transfer four 1 mL CSF aliquots to ARUP standard transport tubes. (Min: 2.8 mL)

Storage/Transport Temperature

Frozen

Unacceptable Conditions

Fluid other than CSF. Grossly hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (Three freeze/thaw cycles are acceptable)

Reference Interval

Test Number
 Components
 Reference Interval
  N-methyl-D-Aspartate Receptor Ab, CSF Less than 1:1
  Paraneoplastic Abs (PCCA/ANNA) IgG, CSF None Detected
  AMPA Receptor Ab IgG Screen, CSF Less than 1:1
  GABA-B Receptor Ab IgG Screen, CSF Less than 1:1
  CASPR2 Ab IgG Screen by IFA, CSF Less than 1:1
  Voltage-Gated Potassium Channel Ab, CSF 0.0-1.1 pmol/L
  LGI1 Ab IgG Screen by IFA, CSF Less than 1:1
  CV2.1 Ab IgG Screen, CSF Less than 1:1
  Glutamic Acid Decarboxylase Antibody CSF 0.0-5.0 IU/mL
  SOX1 Antibody, IgG by Immunoblot, CSF Negative
  Amphiphysin Antibody, CSF Negative
  DPPX Ab IgG CBA IFA Screen, CSF Less than 1:1
  ITPR1 Ab IgG CBA-IFA Screen, CSF Less than 1:1
  IgLON5 Ab IgG CBA-IFA Screen, CSF Less than 1:1
  GABA-AR Ab IgG CBA-IFA Screen, CSF Less than 1:1
  mGluR1 Ab IgG CBA-IFA Screen, CSF Less than 1:1

Interpretive Data

Refer to Report


Component
 Interpretive Data
Voltage-Gated Potassium Channel Ab, CSF 0.0-1.1 pmol/L: Negative
1.2 pmol/L or greater: Positive

Compliance Category

Laboratory Developed Test (LDT)

Note

If NMDA CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If AMPA CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-BR CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If CASPR2 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
PCCA/ANNA CSF antibodies are screened by IFA. If the IFA screen is indeterminate, then the Immunoblot will be added. If the IFA screen is positive at 1:1, then a specific titer (PCCA or ANNA) and Immunoblot will be added. Additional charges apply.
If LGI1 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If CV2.1 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If DPPX CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If ITPR1 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If IgLON5 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-AR CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If mGLUR1 antibody IgG is positive, then titer will be added. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/21/2023
X
N/A

CPT Codes

86255 x12; 83519; 86341; 84182 x2; if reflexed, add 84182 x4; 86256 per titer

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Components

Component Test Code* Component Chart Name LOINC
2005165 N-methyl-D-Aspartate Receptor Ab, CSF 80220-7
2010842 Paraneoplastic Abs (PCCA/ANNA) IgG, CSF 14247-1
3001258 AMPA Receptor Ab IgG Screen, CSF 82732-9
3001268 GABA-B Receptor Ab IgG Screen, CSF 82984-6
3001388 Voltage-Gated Potassium Channel Ab, CSF 68913-3
3001987 CASPR2 Ab IgG Screen by IFA, CSF 90820-2
3001991 LGI1 Ab IgG Screen by IFA, CSF 90830-1
3002259 CV2.1 Ab IgG Screen, CSF 53707-6
3002789 Glutamic Acid Decarboxylase Antibody CSF 42501-7
3002904 SOX1 Antibody, IgG by Immunoblot, CSF 94383-7
3004511 Amphiphysin Antibody, CSF 57750-2
3004513 DPPX Ab IgG CBA IFA Screen, CSF 94283-9
3006004 GABA-AR Ab IgG CBA-IFA Screen, CSF
3006014 IgLON5 Ab IgG CBA-IFA Screen, CSF 96481-7
3006024 ITPR1 Ab IgG CBA-IFA Screen, CSF 96468-4
3006040 mGluR1 Ab IgG CBA-IFA Screen, CSF 93500-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • AMPA
  • amphiphysin
  • ANNA
  • CASPR2
  • CRMP5
  • CV2
  • dementia
  • DNER
  • DPPX
  • dysautonomia
  • encephalitis
  • encephalopathy
  • epilepsy
  • GABA-A
  • GABA-B
  • GAD
  • GAD 65
  • GAD65
  • Hu
  • IgLON5
  • ITPR1
  • LGI1
  • mGluR1
  • movement disorders
  • myelopathy
  • NMDA
  • paraneoplastic
  • PCCA
  • Ri
  • Sox-1
  • Tr
  • VGKC
  • Yo
Autoimmune Neurologic Disease Panel With Reflex, CSF