Ordering Recommendation
Comprehensive panel for the evaluation of paraneoplastic disorders and/or encephalitis in the presence or absence of malignancy.
Mnemonic
Methodology
Semiquantitative Cell-Based Indirect Fluorescent Antibody/Qualitative Immunoblot/Quantitative Radioimmunoassay/Semiquantitative Enzyme-Linked Immunosorbent Assay
Performed
Tue
Reported
3-10 days
New York DOH Approval Status
Specimen Required
CSF
Transfer four 1 mL CSF aliquots to ARUP standard transport tubes. (Min: 2.8 mL)
Frozen
Fluid other than CSF. Grossly hemolyzed specimens.
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (Three freeze/thaw cycles are acceptable)
Reference Interval
Test Number |
Components |
Reference Interval |
---|---|---|
N-methyl-D-Aspartate Receptor Ab, CSF | Less than 1:1 | |
Paraneoplastic Abs (PCCA/ANNA) IgG, CSF | None Detected | |
AMPA Receptor Ab IgG Screen, CSF | Less than 1:1 | |
GABA-B Receptor Ab IgG Screen, CSF | Less than 1:1 | |
CASPR2 Ab IgG Screen by IFA, CSF | Less than 1:1 | |
Voltage-Gated Potassium Channel Ab, CSF | 0.0-1.1 pmol/L | |
LGI1 Ab IgG Screen by IFA, CSF | Less than 1:1 | |
CV2.1 Ab IgG Screen, CSF | Less than 1:1 | |
Glutamic Acid Decarboxylase Antibody CSF | 0.0-5.0 IU/mL | |
SOX1 Antibody, IgG by Immunoblot, CSF | Negative | |
Amphiphysin Antibody, CSF | Negative | |
DPPX Ab IgG CBA IFA Screen, CSF | Less than 1:1 | |
ITPR1 Ab IgG CBA-IFA Screen, CSF | Less than 1:1 | |
IgLON5 Ab IgG CBA-IFA Screen, CSF | Less than 1:1 | |
GABA-AR Ab IgG CBA-IFA Screen, CSF | Less than 1:1 | |
mGluR1 Ab IgG CBA-IFA Screen, CSF | Less than 1:1 |
Interpretive Data
Refer to Report
Component |
Interpretive Data |
---|---|
Voltage-Gated Potassium Channel Ab, CSF | 0.0-1.1 pmol/L: Negative 1.2 pmol/L or greater: Positive |
Laboratory Developed Test (LDT)
Note
If NMDA CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If AMPA CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-BR CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If CASPR2 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
PCCA/ANNA CSF antibodies are screened by IFA. If the IFA screen is indeterminate, then the Immunoblot will be added. If the IFA screen is positive at 1:1, then a specific titer (PCCA or ANNA) and Immunoblot will be added. Additional charges apply.
If LGI1 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If CV2.1 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If DPPX CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If ITPR1 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If IgLON5 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-AR CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If mGLUR1 antibody IgG is positive, then titer will be added. Additional charges apply.
Hotline History
Hotline History
CPT Codes
86255 x12; 83519; 86341; 84182 x2; if reflexed, add 84182 x4; 86256 per titer
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2005165 | N-methyl-D-Aspartate Receptor Ab, CSF | 80220-7 |
2010842 | Paraneoplastic Abs (PCCA/ANNA) IgG, CSF | 14247-1 |
3001258 | AMPA Receptor Ab IgG Screen, CSF | 82732-9 |
3001268 | GABA-B Receptor Ab IgG Screen, CSF | 82984-6 |
3001388 | Voltage-Gated Potassium Channel Ab, CSF | 68913-3 |
3001987 | CASPR2 Ab IgG Screen by IFA, CSF | 90820-2 |
3001991 | LGI1 Ab IgG Screen by IFA, CSF | 90830-1 |
3002259 | CV2.1 Ab IgG Screen, CSF | 53707-6 |
3002789 | Glutamic Acid Decarboxylase Antibody CSF | 42501-7 |
3002904 | SOX1 Antibody, IgG by Immunoblot, CSF | 94383-7 |
3004511 | Amphiphysin Antibody, CSF | 57750-2 |
3004513 | DPPX Ab IgG CBA IFA Screen, CSF | 94283-9 |
3006004 | GABA-AR Ab IgG CBA-IFA Screen, CSF | |
3006014 | IgLON5 Ab IgG CBA-IFA Screen, CSF | 96481-7 |
3006024 | ITPR1 Ab IgG CBA-IFA Screen, CSF | 96468-4 |
3006040 | mGluR1 Ab IgG CBA-IFA Screen, CSF | 93500-7 |
Aliases
- AMPA
- amphiphysin
- ANNA
- CASPR2
- CRMP5
- CV2
- dementia
- DNER
- DPPX
- dysautonomia
- encephalitis
- encephalopathy
- epilepsy
- GABA-A
- GABA-B
- GAD
- GAD 65
- GAD65
- Hu
- IgLON5
- ITPR1
- LGI1
- mGluR1
- movement disorders
- myelopathy
- NMDA
- paraneoplastic
- PCCA
- Ri
- Sox-1
- Tr
- VGKC
- Yo