3006051
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Autoimmune Neurologic Disease Panel with Reflex, Serum

NEURO R4
Example Reports
Negative
Positive

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Additional Technical Information

Ordering Recommendation

Use to evaluate suspected autoimmune disease of the central and peripheral nervous system. 

Targeted phenotype-specific panels are preferred for the evaluation of autoimmune neurologic disease. Refer to the Autoimmune Neurologic Disease Panel With Reflex, Serum and CSF Test Fact Sheet for phenotype-specific test options. 

Testing in both serum and CSF is recommended for suspected encephalitis and/or paraneoplastic disorders to maximize diagnostic yield; refer to Autoimmune Neurologic Disease Panel With Reflex, CSF (3006052) for CSF testing.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube (SST)

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer four 1 mL serum aliquots to ARUP standard transport tubes. (Min: 2.8 mL)

Storage/Transport Temperature

Frozen

Unacceptable Conditions

Amniotic fluid, ocular fluid, peritoneal fluid, synovial fluid, CSF, or plasma. Contaminated, grossly hemolyzed, icteric, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (Three freeze/thaw cycles are acceptable)

Methodology

Semi-Quantitative Cell-Based Indirect Fluorescent Antibody/Qualitative Immunoblot/Quantitative Radioimmunoassay (RIA)/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Tue

Reported

3-10 days

Reference Interval

Test Number
 Components
 Reference Interval
  Neuronal Antibody (Amphiphysin) Negative
  P/Q-Type Calcium Channel Antibody 24.5 pmol/L or less
  Glutamic Acid Decarboxylase Antibody 0.0-5.0 IU/mL
  NMDA Receptor Ab IgG CBA-IFA, Serum Less than 1:10
  Voltage-Gated Potassium Channel Ab, Ser 31 pmol/L or less
  Purkinje Cell/Neuronal Nuclear IgG Scrn None Detected
  CASPR2 Ab IgG CBA-IFA Screen, Serum Less than 1:10
  LGI1 Ab IgG CBA-IFA Screen, Serum Less than 1:10
  NMO/AQP4 Ab IgG CBA-IFA Screen, Serum Less than 1:10
  CV2 Ab IgG CBA-IFA Screen, Serum Less than 1:100
  AMPA Receptor Ab IgG CBA-IFA Scrn, Serum Less than 1:10
  GABA-BR Ab IgG CBA-IFA Scrn, Ser Less than 1:10
  MOG Ab IgG CBA-IFA Screen, Serum Less than 1:10
  SOX1 Antibody, IgG by Immunoblot, Serum Negative
  Ganglionic Acetylcholine Receptor Ab 8.4 pmol/L or less
  DPPX Ab IgG CBA-IFA Screen, Serum Less than 1:10
  ITPR1 Ab IgG CBA-IFA Screen, Serum Less than 1:10
  IgLON5 Ab IgG CBA-IFA Screen, Serum Less than 1:10
  GABA-AR Ab IgG CBA-IFA Screen, Serum Less than 1:10
  mGluR1 Ab IgG CBA-IFA Screen, Serum Less than 1:10

Interpretive Data

Refer to Report


Component
 Interpretation
Voltage-Gated Potassium Channel (VGKC) Antibody, Serum 31 pmol/L or less: Negative
32-87 pmol/L: Indeterminate
88 pmol/L or greater: Positive
P/Q-Type Voltage-Gated Calcium Channel (VGCC) Antibody 0.0 to 24.5 pmol/L: Negative
24.6 to 45.6 pmol/L: Indeterminate
45.7 pmol/L or greater: Positive
Ganglionic Acetylcholine Receptor Antibody 0.0 to 8.4 pmol/L: Negative
8.5 to 11.6 pmol/L: Indeterminate
11.7 pmol/L or greater: Positive

Compliance Category

Laboratory Developed Test (LDT)

Note

If N-methyl-D-Aspartate Receptor Antibody is positive, then titer will be performed. Additional charges apply.
If CV2 Antibody IgG Screen by IFA is positive, then titer will be performed, and Acetylcholine Receptor Binding Antibody will be added. Additional charges apply.
If AQP4 antibody IgG is positive, then titer will be added. Additional charges apply.
If PCCA/ANNA antibody IgG is screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be performed. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot will be performed. Additional charges apply.
If LGI1 antibody IgG is positive, then titer will be added. Additional charges apply.
If CASPR2 antibody IgG is positive, then titer will be added. Additional charges apply.
If AMPAR antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-BR antibody IgG is positive, then titer will be added. Additional charges apply.
If MOG antibody IgG is positive, then titer will be added. Additional charges apply.
If DPPX antibody IgG is positive, then titer will be added. Additional charges apply.
If ITPR1 antibody IgG is positive, then titer will be added. Additional charges apply.
If IgLON5 antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-AR antibody IgG is positive, then titer will be added. Additional charges apply.
If mGLUR1 antibody IgG is positive, then titer will be added. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/20/2024
X
X
X
08/21/2023
X
X
02/21/2023
X
N/A

CPT Codes

83519 x2; 84182 x2; 86255 x12; 86341; 86052; 86362; 86596; if reflexed, add 84182 x4; 86041; 86256

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Components

Component Test Code* Component Chart Name LOINC
0051709 Neuronal Antibody (Amphiphysin) 94385-2
0092629 P/Q-Type Calcium Channel Antibody 33980-4
2001772 Glutamic Acid Decarboxylase Antibody 56540-8
2004222 NMDA Receptor Ab IgG CBA-IFA, Serum 80221-5
2004890 Voltage-Gated Potassium Channel Ab, Ser 41871-5
2007962 Purkinje Cell/Neuronal Nuclear IgG Scrn 61177-2
2009453 CASPR2 Ab IgG CBA-IFA Screen, Serum 82979-6
2009457 LGI1 Ab IgG CBA-IFA Screen, Serum 82978-8
2013322 NMO/AQP4 Ab IgG CBA-IFA Screen, Serum 63439-4
2013959 CV2 Ab IgG CBA-IFA Screen, Serum 72504-4
3001261 AMPA Receptor Ab IgG CBA-IFA Scrn, Serum 82733-7
3001271 GABA-BR Ab IgG CBA-IFA Scrn, Ser 93428-1
3001278 MOG Ab IgG CBA-IFA Screen, Serum 91545-4
3002903 SOX1 Antibody, IgG by Immunoblot, Serum 82444-1
3003019 Ganglionic Acetylcholine Receptor Ab 42233-7
3004361 DPPX Ab IgG CBA-IFA Screen, Serum 94676-4
3006009 GABA-AR Ab IgG CBA-IFA Screen, Serum
3006019 IgLON5 Ab IgG CBA-IFA Screen, Serum 96478-3
3006032 ITPR1 Ab IgG CBA-IFA Screen, Serum 96466-8
3006045 mGluR1 Ab IgG CBA-IFA Screen, Serum 93498-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • AMPA
  • amphiphysin
  • ANNA
  • AQP4
  • CASPR2
  • CRMP5
  • CV2
  • dementia
  • DNER
  • DPPX
  • dysautonomia
  • encephalitis
  • encephalopathy
  • epilepsy
  • GABA-A
  • GABA-B
  • GAD
  • GAD 65
  • GAD65
  • ganglionic
  • Hu
  • IgLON5
  • ITPR1
  • LGI1
  • mGluR1
  • MOG
  • movement disorders
  • myelopathy
  • NMDA
  • paraneoplastic
  • PCCA
  • Ri
  • Sox-1
  • Tr
  • VGCC
  • VGKC
  • Yo
Autoimmune Neurologic Disease Panel with Reflex, Serum