Ordering Recommendation
Comprehensive panel for the evaluation of paraneoplastic and neuromuscular junction disorders, and/or encephalitis, in the presence or absence of malignancy.
Mnemonic
Methodology
Semiquantitative Cell-Based Indirect Fluorescent Antibody/Qualitative Immunoblot/Quantitative Radioimmunoassay/Semiquantitative Enzyme-Linked Immunosorbent Assay
Performed
Tue
Reported
3-10 days
New York DOH Approval Status
Specimen Required
Serum Separator Tube (SST)
Separate from cells ASAP or within 2 hours of collection. Transfer four 1 mL serum aliquots to ARUP standard transport tubes. (Min: 2.8 mL)
Frozen
Amniotic fluid, ocular fluid, peritoneal fluid, synovial fluid, CSF, or plasma. Contaminated, grossly hemolyzed, icteric, or lipemic specimens.
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (Three freeze/thaw cycles are acceptable)
Reference Interval
Test Number |
Components |
Reference Interval |
---|---|---|
Neuronal Antibody (Amphiphysin) | Negative | |
P/Q-Type Calcium Channel Antibody | 24.5 pmol/L or less | |
Glutamic Acid Decarboxylase Antibody | 0.0-5.0 IU/mL | |
N-methyl-D-Aspartate Receptor Ab, Serum | Less than 1:10 | |
Voltage-Gated Potassium Channel Ab, Ser | 31 pmol/L or less | |
Purkinje Cell/Neuronal Nuclear IgG Scrn | None Detected | |
CASPR2 Ab IgG Screen by IFA, Serum | Less than 1:10 | |
LGI1 Ab IgG Screen by IFA, Serum | Less than 1:10 | |
Neuromyelitis Optica/AQP4-IgG, Serum | Less than 1:10 | |
CV2.1 Antibody IgG Screen by IFA | Less than 1:10 | |
AMPA Receptor Ab IgG Screen, Serum | Less than 1:10 | |
GABA-B Receptor Ab IgG Screen, Serum | Less than 1:10 | |
MOG Antibody IgG Screen, Serum | Less than 1:10 | |
SOX1 Antibody, IgG by Immunoblot, Serum | Negative | |
Ganglionic Acetylcholine Receptor Ab | 8.4 pmol/L or less | |
DPPX Ab IgG CBA IFA Screen, Serum | Less than 1:10 | |
ITPR1 Ab IgG CBA-IFA Screen, Serum | Less than 1:10 | |
IgLON5 Ab IgG CBA-IFA Screen, Serum | Less than 1:10 | |
GABA-AR Ab IgG CBA-IFA Screen, Serum | Less than 1:10 | |
mGluR1 Ab IgG CBA-IFA Screen, Serum | Less than 1:10 |
Interpretive Data
Refer to Report
Component |
Interpretation |
---|---|
Voltage-Gated Potassium Channel (VGKC) Antibody, Serum | 31 pmol/L or less: Negative 32-87 pmol/L: Indeterminate 88 pmol/L or greater: Positive |
P/Q-Type Voltage-Gated Calcium Channel (VGCC) Antibody | 0.0 to 24.5 pmol/L: Negative 24.6 to 45.6 pmol/L: Indeterminate 45.7 pmol/L or greater: Positive |
Ganglionic Acetylcholine Receptor Antibody | 0.0 - 8.4 pmol/L: Negative 8.5 - 11.6 pmol/L: Indeterminate 11.7 pmol/L or greater: Positive |
Laboratory Developed Test (LDT)
Note
If N-methyl-D-Aspartate Receptor Antibody is positive, then titer will be performed. Additional charges apply.
If CV2.1 Antibody IgG Screen by IFA is positive, then titer will be performed, and Acetylcholine Receptor Binding Antibody will be added. Additional charges apply.
If AQP4 antibody IgG is positive, then titer will be added. Additional charges apply.
If PCCA/ANNA antibody IgG is screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be performed. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot will be performed. Additional charges apply.
If LGI1 antibody IgG is positive, then titer will be added. Additional charges apply.
If CASPR2 antibody IgG is positive, then titer will be added. Additional charges apply.
If AMPAR antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-BR antibody IgG is positive, then titer will be added. Additional charges apply.
If MOG antibody IgG is positive, then titer will be added. Additional charges apply.
If DPPX antibody IgG is positive, then titer will be added. Additional charges apply.
If ITPR1 antibody IgG is positive, then titer will be added. Additional charges apply.
If IgLON5 antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-AR antibody IgG is positive, then titer will be added. Additional charges apply.
If mGLUR1 antibody IgG is positive, then titer will be added. Additional charges apply.
Hotline History
Hotline History
CPT Codes
83519 x2; 84182 x2; 86255 x12; 86341; 86052; 86362; 86596; if reflexed, add 83519; 84182 x4; 86256 per titer
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0051709 | Neuronal Antibody (Amphiphysin) | 94385-2 |
0092629 | P/Q-Type Calcium Channel Antibody | 33980-4 |
2001772 | Glutamic Acid Decarboxylase Antibody | 56540-8 |
2004222 | N-methyl-D-Aspartate Receptor Ab, Serum | 80221-5 |
2004890 | Voltage-Gated Potassium Channel Ab, Ser | 41871-5 |
2007962 | Purkinje Cell/Neuronal Nuclear IgG Scrn | 61177-2 |
2009453 | CASPR2 Ab IgG Screen by IFA, Serum | 82979-6 |
2009457 | LGI1 Ab IgG Screen by IFA, Serum | 82978-8 |
2013322 | Neuromyelitis Optica/AQP4-IgG, Serum | 63439-4 |
2013959 | CV2.1 Antibody IgG Screen by IFA | 72504-4 |
3001261 | AMPA Receptor Ab IgG Screen, Serum | 82733-7 |
3001271 | GABA-B Receptor Ab IgG Screen, Serum | 93428-1 |
3001278 | MOG Antibody IgG Screen, Serum | 91545-4 |
3002903 | SOX1 Antibody, IgG by Immunoblot, Serum | 82444-1 |
3003019 | Ganglionic Acetylcholine Receptor Ab | 42233-7 |
3004361 | DPPX Ab IgG CBA IFA Screen, Serum | 94676-4 |
3006009 | GABA-AR Ab IgG CBA-IFA Screen, Serum | |
3006019 | IgLON5 Ab IgG CBA-IFA Screen, Serum | 96478-3 |
3006032 | ITPR1 Ab IgG CBA-IFA Screen, Serum | 96466-8 |
3006045 | mGluR1 Ab IgG CBA-IFA Screen, Serum | 93498-4 |
Aliases
- AMPA
- amphiphysin
- ANNA
- AQP4
- CASPR2
- CRMP5
- CV2
- dementia
- DNER
- DPPX
- dysautonomia
- encephalitis
- encephalopathy
- epilepsy
- GABA-A
- GABA-B
- GAD
- GAD 65
- GAD65
- ganglionic
- Hu
- IgLON5
- ITPR1
- LGI1
- mGluR1
- MOG
- movement disorders
- myelopathy
- NMDA
- paraneoplastic
- PCCA
- Ri
- Sox-1
- Tr
- VGCC
- VGKC
- Yo