Autoimmune Encephalitis Extended Panel, Serum
Ordering Recommendation
Use to evaluate suspected autoimmune disease of the central nervous system. This panel does not test for paraneoplastic antibodies; to evaluate for paraneoplastic antibodies in adults or in individuals with suspected cancer, refer to Paraneoplastic Reflexive Panel (3002929).
Targeted phenotype-specific panels include phenotype-relevant paraneoplastic antibodies and are preferred in the evaluation of autoimmune encephalitis. Refer to the ARUP Autoimmune Neurology Panel Components tables for phenotype-specific test options.
Testing in both serum and CSF is recommended to maximize diagnostic yield; refer to Autoimmune Encephalitis Reflex Panel, CSF (3006049) for CSF testing.
Methodology
Semiquantitative Cell-Based Indirect Fluorescent Antibody/Quantitative Radioimmunoassay/Semiquantitative Enzyme-Linked Immunosorbent Assay
Performed
Tue
Reported
3-10 days
New York DOH Approval Status
Specimen Required
Serum Separator Tube (SST).
Separate from cells ASAP or within 2 hours of collection. Transfer three (3) 1 mL serum aliquots to ARUP standard transport tubes. (Min: 1.5 mL)
Frozen.
Contaminated specimens.
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (Three freeze/thaw cycles are acceptable)
Reference Interval
Test Number |
Components |
Reference Interval |
---|---|---|
Glutamic Acid Decarboxylase Antibody | 0.0-5.0 IU/mL | |
NMDA Receptor Ab IgG CBA-IFA, Serum | Less than 1:10 | |
Voltage-Gated Potassium Channel Ab, Ser | 31 pmol/L or less | |
CASPR2 Ab IgG CBA-IFA Screen, Serum | Less than 1:10 | |
LGI1 Ab IgG CBA-IFA Screen, Serum | Less than 1:10 | |
NMO/AQP4 Ab IgG CBA-IFA Screen, Serum | Less than 1:10 | |
AMPA Receptor Ab IgG CBA-IFA Scrn, Serum | Less than 1:10 | |
GABA-BR Ab IgG CBA-IFA Scrn, Ser | Less than 1:10 | |
MOG Ab IgG CBA-IFA Screen, Serum | Less than 1:10 | |
DPPX Ab IgG CBA-IFA Screen, Serum | Less than 1:10 | |
GABA-AR Ab IgG CBA-IFA Screen, Serum | Less than 1:10 | |
IgLON5 Ab IgG CBA-IFA Screen, Serum | Less than 1:10 | |
mGluR1 Ab IgG CBA-IFA Screen, Serum | Less than 1:10 |
Interpretive Data
Refer to report.
Component |
Interpretive Data (pmol/L) |
---|---|
Voltage-Gated Potassium Channel Ab, Ser | 31 or less: Negative 32-87: Indeterminate 88 or greater: Positive |
Laboratory Developed Test (LDT)
Note
If N-methyl-D-Aspartate Receptor antibody is positive, then a titer will be added. Additional charges apply.
If Aquaporin-4 Receptor antibody IgG is positive, then a titer will be added. Additional charges apply.
If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. Additional charges apply.
If CASPR2 antibody IgG is positive, then CASPR2 antibody IgG titer will be added. Additional charges apply.
If AMPAR antibody IgG is positive, then a titer will be added. Additional charges apply.
If GABABR antibody IgG is positive, then a titer will be added. Additional charges apply.
If MOG antibody IgG is positive, then a titer will be added. Additional charges apply.
If DPPX antibody IgG is positive, then a titer will be added. Additional charges apply.
If GABAAR antibody IgG is positive, then a titer will be added. Additional charges apply.
If IgLON5 antibody IgG is positive, then a titer will be added. Additional charges apply.
If mGluR1 antibody IgG is positive, then a titer will be added. Additional charge apply.
Hotline History
Hotline History
CPT Codes
83519; 86052; 86341; 86362; 86255 x9; if reflexed, add 86256 per titer.
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2001772 | Glutamic Acid Decarboxylase Antibody | 56540-8 |
2004222 | NMDA Receptor Ab IgG CBA-IFA, Serum | 80221-5 |
2004890 | Voltage-Gated Potassium Channel Ab, Ser | 41871-5 |
2009453 | CASPR2 Ab IgG CBA-IFA Screen, Serum | 82979-6 |
2009457 | LGI1 Ab IgG CBA-IFA Screen, Serum | 82978-8 |
2013322 | NMO/AQP4 Ab IgG CBA-IFA Screen, Serum | 63439-4 |
3001261 | AMPA Receptor Ab IgG CBA-IFA Scrn, Serum | 82733-7 |
3001271 | GABA-BR Ab IgG CBA-IFA Scrn, Ser | 93428-1 |
3001278 | MOG Ab IgG CBA-IFA Screen, Serum | 91545-4 |
3004361 | DPPX Ab IgG CBA-IFA Screen, Serum | 94676-4 |
3006009 | GABA-AR Ab IgG CBA-IFA Screen, Serum | |
3006019 | IgLON5 Ab IgG CBA-IFA Screen, Serum | 96478-3 |
3006045 | mGluR1 Ab IgG CBA-IFA Screen, Serum | 93498-4 |
Aliases
- AMPA
- AQP4
- CASPR2
- DPPX
- encephalitis
- encephalopathy
- GABA-A
- GABA-B
- GAD
- GAD 65
- GAD65
- IgLON5
- LGI1
- mGluR1
- MOG
- NMDA
- VGKC