3006050
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Autoimmune Encephalitis Extended Panel, Serum

ENCEPHEXT2
Example Reports
Negative
Positive

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Additional Technical Information

Ordering Recommendation

Use to evaluate suspected autoimmune disease of the central nervous system. This panel does not test for paraneoplastic antibodies; to evaluate for paraneoplastic antibodies in adults or in individuals with suspected cancer, refer to Paraneoplastic Reflexive Panel (3002929). 

Targeted phenotype-specific panels include phenotype-relevant paraneoplastic antibodies and are preferred in the evaluation of autoimmune encephalitis. Refer to the ARUP Autoimmune Neurology Panel Components tables for phenotype-specific test options. 

Testing in both serum and CSF is recommended to maximize diagnostic yield; refer to Autoimmune Encephalitis Reflex Panel, CSF (3006049) for CSF testing.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer three (3) 1 mL serum aliquots to ARUP standard transport tubes. (Min: 1.5 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Contaminated specimens.

Remarks
Stability

After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (Three freeze/thaw cycles are acceptable)

Methodology

Semiquantitative Cell-Based Indirect Fluorescent Antibody/Quantitative Radioimmunoassay/Semiquantitative Enzyme-Linked Immunosorbent Assay

Performed

Tue

Reported

3-10 days

Reference Interval

Test Number
 Components
 Reference Interval
  Glutamic Acid Decarboxylase Antibody 0.0-5.0 IU/mL
  NMDA Receptor Ab IgG CBA-IFA, Serum Less than 1:10
  Voltage-Gated Potassium Channel Ab, Ser 31 pmol/L or less
  CASPR2 Ab IgG CBA-IFA Screen, Serum Less than 1:10
  LGI1 Ab IgG CBA-IFA Screen, Serum Less than 1:10
  NMO/AQP4 Ab IgG CBA-IFA Screen, Serum Less than 1:10
  AMPA Receptor Ab IgG CBA-IFA Scrn, Serum Less than 1:10
  GABA-BR Ab IgG CBA-IFA Scrn, Ser Less than 1:10
  MOG Ab IgG CBA-IFA Screen, Serum Less than 1:10
  DPPX Ab IgG CBA-IFA Screen, Serum Less than 1:10
  GABA-AR Ab IgG CBA-IFA Screen, Serum Less than 1:10
  IgLON5 Ab IgG CBA-IFA Screen, Serum Less than 1:10
  mGluR1 Ab IgG CBA-IFA Screen, Serum Less than 1:10

Interpretive Data

Refer to report.


Component
 Interpretive Data (pmol/L)
Voltage-Gated Potassium Channel Ab, Ser 31 or less: Negative
32-87: Indeterminate
88 or greater: Positive

Compliance Category

Laboratory Developed Test (LDT)

Note

If N-methyl-D-Aspartate Receptor antibody is positive, then a titer will be added. Additional charges apply.
If Aquaporin-4 Receptor antibody IgG is positive, then a titer will be added. Additional charges apply.
If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. Additional charges apply.
If CASPR2 antibody IgG is positive, then CASPR2 antibody IgG titer will be added. Additional charges apply.
If AMPAR antibody IgG is positive, then a titer will be added. Additional charges apply.
If GABABR antibody IgG is positive, then a titer will be added. Additional charges apply.
If MOG antibody IgG is positive, then a titer will be added. Additional charges apply.
If DPPX antibody IgG is positive, then a titer will be added. Additional charges apply.
If GABAAR antibody IgG is positive, then a titer will be added. Additional charges apply.
If IgLON5 antibody IgG is positive, then a titer will be added. Additional charges apply.
If mGluR1 antibody IgG is positive, then a titer will be added. Additional charge apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/21/2023
X
02/21/2023
X
N/A

CPT Codes

83519; 86052; 86341; 86362; 86255 x9; if reflexed, add 86256 per titer.

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Components

Component Test Code* Component Chart Name LOINC
2001772 Glutamic Acid Decarboxylase Antibody 56540-8
2004222 NMDA Receptor Ab IgG CBA-IFA, Serum 80221-5
2004890 Voltage-Gated Potassium Channel Ab, Ser 41871-5
2009453 CASPR2 Ab IgG CBA-IFA Screen, Serum 82979-6
2009457 LGI1 Ab IgG CBA-IFA Screen, Serum 82978-8
2013322 NMO/AQP4 Ab IgG CBA-IFA Screen, Serum 63439-4
3001261 AMPA Receptor Ab IgG CBA-IFA Scrn, Serum 82733-7
3001271 GABA-BR Ab IgG CBA-IFA Scrn, Ser 93428-1
3001278 MOG Ab IgG CBA-IFA Screen, Serum 91545-4
3004361 DPPX Ab IgG CBA-IFA Screen, Serum 94676-4
3006009 GABA-AR Ab IgG CBA-IFA Screen, Serum
3006019 IgLON5 Ab IgG CBA-IFA Screen, Serum 96478-3
3006045 mGluR1 Ab IgG CBA-IFA Screen, Serum 93498-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • AMPA
  • AQP4
  • CASPR2
  • DPPX
  • encephalitis
  • encephalopathy
  • GABA-A
  • GABA-B
  • GAD
  • GAD 65
  • GAD65
  • IgLON5
  • LGI1
  • mGluR1
  • MOG
  • NMDA
  • VGKC
Autoimmune Encephalitis Extended Panel, Serum