Autoimmune Encephalitis Reflex Panel, CSF
Ordering Recommendation
Use to evaluate suspected autoimmune disease of the central nervous system. This panel does not test for paraneoplastic antibodies; to evaluate for paraneoplastic antibodies in adults or in individuals with suspected cancer, refer to Paraneoplastic Reflexive Panel (3002929).
Targeted phenotype-specific panels are preferred in the evaluation of autoimmune encephalitis. Refer to the ARUP Autoimmune Neurology Panel Components tables for phenotype-specific test options.
Testing in both serum and CSF is recommended to maximize diagnostic yield; refer to Autoimmune Encephalitis Extended Panel, Serum (3006050) for serum testing.
Methodology
Semiquantitative Cell-Based Indirect Fluorescent Antibody/Quantitative Radioimmunoassay/Semiquantitative Enzyme-Linked Immunosorbent Assay
Performed
Tue
Reported
3-10 days
New York DOH Approval Status
Specimen Required
CSF
Transfer three (3) 1 mL CSF aliquots to ARUP standard transport tubes. (Min: 1.5 mL)
Frozen.
Contaminated specimens.
Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (Three freeze/thaw cycles are acceptable)
Reference Interval
Test Number |
Components |
Reference Interval |
---|---|---|
Glutamic Acid Decarboxylase Antibody CSF | 0.0-5.0 IU/mL | |
NMDA Receptor Ab IgG CBA-IFA, CSF | Less than 1:1 | |
NMO/AQP4 Ab IgG CBA-IFA Screen, CSF | Less than 1:1 | |
AMPA Receptor Ab IgG CBA-IFA Screen, CSF | Less than 1:1 | |
GABA-BR Ab IgG CBA-IFA Screen, CSF | Less than 1:1 | |
Voltage-Gated Potassium Channel Ab, CSF | 0.0-1.1 pmol/L | |
CASPR2 Ab IgG CBA-IFA Screen, CSF | Less than 1:1 | |
LGI1 Ab IgG CBA-IFA Screen, CSF | Less than 1:1 | |
DPPX Ab IgG CBA-IFA Screen, CSF | Less than 1:1 | |
IgLON5 Ab IgG CBA-IFA Screen, CSF | Less than 1:1 | |
GABA-AR Ab IgG CBA-IFA Screen, CSF | Less than 1:1 | |
mGluR1 Ab IgG CBA-IFA Screen, CSF | Less than 1:1 |
Interpretive Data
Refer to report.
Component |
Interpretation |
---|---|
Voltage-Gated Potassium Channel Ab, CSF | 0.0-1.1 pmol/L: Negative 1.2 pmol/L or greater: Positive |
Laboratory Developed Test (LDT)
Note
If NMDA CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If AQP4 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If AMPA CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-BR CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If CASPR2 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If LGI1 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If DPPX CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If IgLON5 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-AR CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If mGluR1 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
Hotline History
Hotline History
CPT Codes
86052; 86255 x9; 83519; 86341; if reflexed, add 86256 per titer.
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2005165 | NMDA Receptor Ab IgG CBA-IFA, CSF | 80220-7 |
2011700 | NMO/AQP4 Ab IgG CBA-IFA Screen, CSF | 46718-3 |
3001258 | AMPA Receptor Ab IgG CBA-IFA Screen, CSF | 82732-9 |
3001268 | GABA-BR Ab IgG CBA-IFA Screen, CSF | 82984-6 |
3001388 | Voltage-Gated Potassium Channel Ab, CSF | 68913-3 |
3001987 | CASPR2 Ab IgG CBA-IFA Screen, CSF | 90820-2 |
3001991 | LGI1 Ab IgG CBA-IFA Screen, CSF | 90830-1 |
3002789 | Glutamic Acid Decarboxylase Antibody CSF | 42501-7 |
3004513 | DPPX Ab IgG CBA-IFA Screen, CSF | 94283-9 |
3006004 | GABA-AR Ab IgG CBA-IFA Screen, CSF | |
3006014 | IgLON5 Ab IgG CBA-IFA Screen, CSF | 96481-7 |
3006040 | mGluR1 Ab IgG CBA-IFA Screen, CSF | 93500-7 |
Aliases
- AMPA
- AQP4
- CASPR2
- DPPX
- encephalitis
- encephalopathy
- GABA-A
- GABA-B
- GAD
- GAD 65
- GAD65
- IgLON5
- LGI1
- mGluR1
- NMDA
- VGKC