3006049
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Autoimmune Encephalitis Reflex Panel, CSF

AE CSF
Example Reports
Negative
Positive

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Additional Technical Information

Ordering Recommendation

Use to evaluate suspected autoimmune disease of the central nervous system. This panel does not test for paraneoplastic antibodies; to evaluate for paraneoplastic antibodies in adults or in individuals with suspected cancer, refer to Paraneoplastic Reflexive Panel (3002929). 

Targeted phenotype-specific panels are preferred in the evaluation of autoimmune encephalitis. Refer to the ARUP Autoimmune Neurology Panel Components tables for phenotype-specific test options. 

Testing in both serum and CSF is recommended to maximize diagnostic yield; refer to Autoimmune Encephalitis Extended Panel, Serum (3006050) for serum testing.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

CSF

Specimen Preparation

Transfer three (3) 1 mL CSF aliquots to ARUP standard transport tubes. (Min: 1.5 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Contaminated specimens.

Remarks
Stability

Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (Three freeze/thaw cycles are acceptable)

Methodology

Semiquantitative Cell-Based Indirect Fluorescent Antibody/Quantitative Radioimmunoassay/Semiquantitative Enzyme-Linked Immunosorbent Assay

Performed

Tue

Reported

3-10 days

Reference Interval

Test Number
 Components
 Reference Interval
  Glutamic Acid Decarboxylase Antibody CSF 0.0-5.0 IU/mL
  NMDA Receptor Ab IgG CBA-IFA, CSF Less than 1:1
  NMO/AQP4 Ab IgG CBA-IFA Screen, CSF Less than 1:1
  AMPA Receptor Ab IgG CBA-IFA Screen, CSF Less than 1:1
  GABA-BR Ab IgG CBA-IFA Screen, CSF Less than 1:1
  Voltage-Gated Potassium Channel Ab, CSF 1.1 pmol/L or less
  CASPR2 Ab IgG CBA-IFA Screen, CSF Less than 1:1
  LGI1 Ab IgG CBA-IFA Screen, CSF Less than 1:1
  DPPX Ab IgG CBA-IFA Screen, CSF Less than 1:1
  IgLON5 Ab IgG CBA-IFA Screen, CSF Less than 1:1
  GABA-AR Ab IgG CBA-IFA Screen, CSF Less than 1:1
  mGluR1 Ab IgG CBA-IFA Screen, CSF Less than 1:1

Interpretive Data

Refer to report.


Component
 Interpretation
Voltage-Gated Potassium Channel Ab, CSF 0.0-1.1 pmol/L: Negative
1.2 pmol/L or greater: Positive

Compliance Category

Laboratory Developed Test (LDT)

Note

If NMDA CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If AQP4 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If AMPA CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-BR CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If CASPR2 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If LGI1 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If DPPX CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If IgLON5 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-AR CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If mGluR1 CSF antibody IgG is positive, then titer will be added. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/21/2023
X
02/21/2023
X
N/A

CPT Codes

86052; 86255 x9; 83519; 86341; if reflexed, add 86256 per titer.

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Components

Component Test Code* Component Chart Name LOINC
2005165 NMDA Receptor Ab IgG CBA-IFA, CSF 80220-7
2011700 NMO/AQP4 Ab IgG CBA-IFA Screen, CSF 46718-3
3001258 AMPA Receptor Ab IgG CBA-IFA Screen, CSF 82732-9
3001268 GABA-BR Ab IgG CBA-IFA Screen, CSF 82984-6
3001388 Voltage-Gated Potassium Channel Ab, CSF 68913-3
3001987 CASPR2 Ab IgG CBA-IFA Screen, CSF 90820-2
3001991 LGI1 Ab IgG CBA-IFA Screen, CSF 90830-1
3002789 Glutamic Acid Decarboxylase Antibody CSF 42501-7
3004513 DPPX Ab IgG CBA-IFA Screen, CSF 94283-9
3006004 GABA-AR Ab IgG CBA-IFA Screen, CSF
3006014 IgLON5 Ab IgG CBA-IFA Screen, CSF 96481-7
3006040 mGluR1 Ab IgG CBA-IFA Screen, CSF 93500-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • AMPA
  • AQP4
  • CASPR2
  • DPPX
  • encephalitis
  • encephalopathy
  • GABA-A
  • GABA-B
  • GAD
  • GAD 65
  • GAD65
  • IgLON5
  • LGI1
  • mGluR1
  • NMDA
  • VGKC
Autoimmune Encephalitis Reflex Panel, CSF