Autoimmune Encephalitis Reflex Panel, CSF

3006049
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Ordering Recommendation

Aids in the differential evaluation of encephalitis of unknown origin with subacute onset of seizures, confusion, memory loss, and/or behavioral change. For adults and patients with suspicion of cancer, additional evaluation of paraneoplastic autoantibodies is recommended; refer to Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot, CSF (2010841).

Mnemonic

AE CSF

Methodology

Semiquantitative Cell-Based Indirect Fluorescent Antibody/Quantitative Radioimmunoassay/Semiquantitative Enzyme-Linked Immunosorbent Assay

Performed

Tue

Reported

3-10 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

CSF

Specimen Preparation

Transfer three (3) 1 mL CSF aliquots to ARUP standard transport tubes. (Min: 1.5 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Contaminated specimens.

Remarks
Stability

Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (Three freeze/thaw cycles are acceptable)

Reference Interval

Test Number
 Components
 Reference Interval
  Glutamic Acid Decarboxylase Antibody CSF 0.0-5.0 IU/mL
  N-methyl-D-Aspartate Receptor Ab, CSF Less than 1:1
  Neuromyelitis Optica/AQP4-IgG, CSF Less than 1:1
  AMPA Receptor Ab IgG Screen, CSF Less than 1:1
  GABA-B Receptor Ab IgG Screen, CSF Less than 1:1
  Voltage-Gated Potassium Channel Ab, CSF 0.0-1.1 pmol/L
  CASPR2 Ab IgG Screen by IFA, CSF Less than 1:1
  LGI1 Ab IgG Screen by IFA, CSF Less than 1:1
  DPPX Ab IgG CBA IFA Screen, CSF Less than 1:1
  IgLON5 Ab IgG CBA-IFA Screen, CSF Less than 1:1
  GABA-AR Ab IgG CBA-IFA Screen, CSF Less than 1:1
  mGluR1 Ab IgG CBA-IFA Screen, CSF Less than 1:1

Interpretive Data

Refer to report.


Component
 Interpretation
Voltage-Gated Potassium Channel Ab, CSF 0.0-1.1 pmol/L: Negative
1.2 pmol/L or greater: Positive

Compliance Category

Laboratory Developed Test (LDT)

Note

If NMDA CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If AQP4 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If AMPA CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-BR CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If CASPR2 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If LGI1 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If DPPX CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If IgLON5 CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If GABA-AR CSF antibody IgG is positive, then titer will be added. Additional charges apply.
If mGluR1 CSF antibody IgG is positive, then titer will be added. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/21/2023
X
N/A

CPT Codes

86052; 86255 x9; 83519; 86341; if reflexed, add 86256 per titer.

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Components

Component Test Code* Component Chart Name LOINC
2005165 N-methyl-D-Aspartate Receptor Ab, CSF 80220-7
2011700 Neuromyelitis Optica/AQP4-IgG, CSF 46718-3
3001258 AMPA Receptor Ab IgG Screen, CSF 82732-9
3001268 GABA-B Receptor Ab IgG Screen, CSF 82984-6
3001388 Voltage-Gated Potassium Channel Ab, CSF 68913-3
3001987 CASPR2 Ab IgG Screen by IFA, CSF 90820-2
3001991 LGI1 Ab IgG Screen by IFA, CSF 90830-1
3002789 Glutamic Acid Decarboxylase Antibody CSF 42501-7
3004513 DPPX Ab IgG CBA IFA Screen, CSF 94283-9
3006004 GABA-AR Ab IgG CBA-IFA Screen, CSF
3006014 IgLON5 Ab IgG CBA-IFA Screen, CSF 96481-7
3006040 mGluR1 Ab IgG CBA-IFA Screen, CSF 93500-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • AMPA
  • AQP4
  • CASPR2
  • DPPX
  • encephalitis
  • encephalopathy
  • GABA-A
  • GABA-B
  • GAD
  • GAD 65
  • GAD65
  • IgLON5
  • LGI1
  • mGluR1
  • NMDA
  • VGKC
Autoimmune Encephalitis Reflex Panel, CSF