Metabotropic Glutamate Receptor 1 (mGluR1) Antibody, IgG by CBA-IFA With Reflex to Titer, CSF
Aids in the diagnosis of cerebellar ataxia and limbic encephalitis. May be used to monitor treatment response in individuals who are antibody positive. The presence of mGluR1 antibodies may be associated with subacute cerebellar ataxia, dysgeusia, dysarthria, head titubation, and cognitive impairment. mGluR1 encephalitis may be paraneoplastic; hematologic malignancies are reported in a subset of patients.
Semiquantitative Cell-Based Indirect Fluorescent Antibody
New York DOH Approval Status
Transfer 0.5 mL CSF to an ARUP standard transport tube. (Min: 0.15 mL)
Grossly hemolyzed or contaminated specimens.
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month (Three freeze/thaw cycles are acceptable)
|mGluR1 Ab IgG CBA-IFA Screen, CSF||Less than 1:1|
Metabotropic glutamate receptor 1 (mGluR1) antibody is found in a subset of patients with autoimmune cerebellar ataxia or autoimmune encephalitis and may occur with or without associated tumor. A negative test result does not rule out a diagnosis of autoimmune cerebellar ataxia or limbic encephalitis. Interpretation of any antineural antibody test requires clinical correlation.
This indirect fluorescent antibody assay utilizes mGluR1 transfected cell lines for detection and semiquantification of mGluR1 IgG antibody.
Laboratory Developed Test (LDT)
If mGluR1 antibody IgG is positive, then mGluR1 antibody IgG titer will be added. Additional charges apply.
86255; if reflexed, add 86256
|Component Test Code*||Component Chart Name||LOINC|
|3006040||mGluR1 Ab IgG CBA-IFA Screen, CSF||93500-7|
- cerebellar ataxia
- Limbic encephalitis
- movement disorder
- pediatric CNS disorder