3006039
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Metabotropic Glutamate Receptor 1 (mGluR1) Antibody, IgG by CBA-IFA With Reflex to Titer, CSF

MGLUR1 CSF
Example Reports
Detected
Not Detected

Ordering Recommendation

Aids in the diagnosis of cerebellar ataxia and limbic encephalitis. May be used to monitor treatment response in individuals who are antibody positive. The presence of mGluR1 antibodies may be associated with subacute cerebellar ataxia, dysgeusia, dysarthria, head titubation, and cognitive impairment. mGluR1 encephalitis may be paraneoplastic; hematologic malignancies are reported in a subset of patients.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Separate CSF.

Specimen Preparation

Transfer 0.5 mL CSF to an ARUP standard transport tube. (Min: 0.15 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Grossly hemolyzed or contaminated specimens.

Remarks
Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month (Three freeze/thaw cycles are acceptable)

Methodology

Semiquantitative Cell-Based Indirect Fluorescent Antibody

Performed

Wed

Reported

1-8 days

Reference Interval

Test Number
 Components
 Reference Interval
  mGluR1 Ab IgG CBA-IFA Screen, CSF Less than 1:1

Interpretive Data

Metabotropic glutamate receptor 1 (mGluR1) antibody is found in a subset of patients with autoimmune cerebellar ataxia or autoimmune encephalitis and may occur with or without associated tumor. A negative test result does not rule out a diagnosis of autoimmune cerebellar ataxia or limbic encephalitis. Interpretation of any antineural antibody test requires clinical correlation.
  
This indirect fluorescent antibody assay utilizes mGluR1 transfected cell lines for detection and semiquantification of mGluR1 IgG antibody.

Compliance Category

Laboratory Developed Test (LDT)

Note

If mGluR1 antibody IgG is positive, then mGluR1 antibody IgG titer will be added. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/21/2023
X
N/A

CPT Codes

86255; if reflexed, add 86256

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Components

Component Test Code* Component Chart Name LOINC
3006040 mGluR1 Ab IgG CBA-IFA Screen, CSF 93500-7
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Aliases

  • cerebellar ataxia
  • dementia
  • encephalitis
  • encephalopathy
  • epilepsy
  • Limbic encephalitis
  • movement disorder
  • myelopathy
  • pediatric CNS disorder
Metabotropic Glutamate Receptor 1 (mGluR1) Antibody, IgG by CBA-IFA With Reflex to Titer, CSF