Ordering Recommendation

Recommended test to confirm a hereditary cause of gastric cancer in individuals with a personal or family history of disease. Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.

Mnemonic

GASCAN NGS

Methodology

Massively Parallel Sequencing/Sequencing/Multiplex Ligation-dependent Probe Amplification

Performed

Varies

Reported

3-6 weeks

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

Lavender or pink (EDTA) or yellow (ACD solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue; DNA.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Genes Tested:  APC*; BMPR1A*; CDH1*; CTNNA1*; EPCAM**; MLH1; MSH2; MSH6; PMS2; SMAD4; STK11; TP53

*One or more exons are not covered by sequencing and/or deletion/duplication analysis for the indicated gene; see Additional Technical Information.
**Deletion/duplication analysis of EPCAM (NM_002354) exon 9 only, sequencing is not available for this gene.

Hotline History

N/A

CPT Codes

81201; 81203; 81292; 81294; 81295; 81297; 81298; 81300; 81317; 81319; 81403

Components

Component Test Code* Component Chart Name LOINC
3005964 Spcm GASCAN
3005965 GASCAN Interp
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • AFAP
  • Familial adenomatous polyposis
  • FAP
  • GAPPS
  • Gastric adenocarcinoma and proximal polyposis of the stomach
  • HDGC
  • Hereditary diffuse gastric cancer
  • Hereditary gastrointestinal cancer
  • Hereditary stomach cancer
  • JPS
  • Juvenile polyposis syndrome
  • Li-Fraumeni syndrome
  • Lynch syndrome
  • Peutz-Jeghers syndrome
  • PJS
Hereditary Gastric Cancer Panel, Sequencing and Deletion/Duplication (Not Orderable)