Ordering Recommendation
Recommended test to confirm a hereditary cause of gastric cancer in individuals with a personal or family history of disease. Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.
To compare this test to other hereditary cancer panels, refer to the ARUP Hereditary Cancer Panel Comparison table.
Mnemonic
Methodology
Massively Parallel Sequencing/Sequencing/Multiplex Ligation-dependent Probe Amplification
Performed
Varies
Reported
21-42 days
New York DOH Approval Status
Specimen Required
Lavender or pink (EDTA) or yellow (ACD solution A or B).
Transport 3 mL whole blood. (Min: 2 mL)
Refrigerated.
Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue; DNA.
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable
Reference Interval
By report
Interpretive Data
Refer to report.
Depends on Specimen/Source/Method
Note
Genes Tested: APC*; BMPR1A*; CDH1*; CTNNA1*; EPCAM**; MLH1; MSH2; MSH6; PMS2; SMAD4; STK11; TP53
*One or more exons are not covered by sequencing and/or deletion/duplication analysis for the indicated gene; see Additional Technical Information.
**Deletion/duplication analysis of EPCAM (NM_002354) exon 9 only, sequencing is not available for this gene.
Hotline History
Hotline History
CPT Codes
81201; 81203; 81292; 81294; 81295; 81297; 81298; 81300; 81317; 81319; 81403
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
3005964 | Spcm GASCAN | |
3005965 | GASCAN Interp |
Aliases
- AFAP
- Familial adenomatous polyposis
- FAP
- GAPPS
- Gastric adenocarcinoma and proximal polyposis of the stomach
- HDGC
- Hereditary diffuse gastric cancer
- Hereditary gastrointestinal cancer
- Hereditary stomach cancer
- JPS
- Juvenile polyposis syndrome
- Li-Fraumeni syndrome
- Lynch syndrome
- Peutz-Jeghers syndrome
- PJS