Hereditary Gastric Cancer Panel, Sequencing and Deletion/Duplication
Recommended test to confirm a hereditary cause of gastric cancer in individuals with a personal or family history of disease. Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.
To compare this test to other hereditary cancer panels, refer to the ARUP Hereditary Cancer Panel Comparison table.
New York DOH Approval Status
Lavender or pink (EDTA) or yellow (ACD solution A or B).
New York State Clients: Lavender (K2EDTA or K3EDTA)
Transport 3 mL whole blood. (Min: 2 mL)
Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue; DNA.
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable
New York State Clients: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: Unacceptable
Massively Parallel Sequencing/Sequencing/Multiplex Ligation-dependent Probe Amplification
Refer to report.
Depends on Specimen/Source/Method
Genes Tested: APC*; BMPR1A*; CDH1*; CTNNA1*; EPCAM**; MLH1; MSH2; MSH6; PMS2; SMAD4; STK11; TP53
*One or more exons are not covered by sequencing and/or deletion/duplication analysis for the indicated gene; see Additional Technical Information.
**Deletion/duplication analysis of EPCAM (NM_002354) exon 9 only, sequencing is not available for this gene.
81201; 81203; 81292; 81294; 81295; 81297; 81298; 81300; 81317; 81319; 81403
|Component Test Code*||Component Chart Name||LOINC|
- Familial adenomatous polyposis
- Gastric adenocarcinoma and proximal polyposis of the stomach
- Hereditary diffuse gastric cancer
- Hereditary gastrointestinal cancer
- Hereditary stomach cancer
- Juvenile polyposis syndrome
- Li-Fraumeni syndrome
- Lynch syndrome
- Peutz-Jeghers syndrome