3005963
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Hereditary Gastric Cancer Panel, Sequencing and Deletion/Duplication

GASCAN NGS
Example Reports
Negative
Positive

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Hereditary Cancer Testing Patient History Form

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Informed Consent for Genetic Testing (Required for NY patients)

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Additional Technical Information

Ordering Recommendation

Recommended test to confirm a hereditary cause of gastric cancer in individuals with a personal or family history of disease. Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.

To compare this test to other hereditary cancer panels, refer to the ARUP Hereditary Cancer Panel Comparison table.

New York DOH Approval Status

Testing is not New York state approved. Specimens from New York clients will be sent out to a New York state-approved laboratory.

Specimen Required

Patient Preparation
Collect

Lavender or pink (EDTA) or yellow (ACD solution A or B).
New York State Clients: Lavender (K2EDTA or K3EDTA)

Specimen Preparation

Transport 3 mL whole blood. (Min: 2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue; DNA.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable
New York State Clients: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: Unacceptable

Methodology

Massively Parallel Sequencing/Sequencing/Multiplex Ligation-dependent Probe Amplification

Performed

Varies

Reported

14-21 days

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Depends on Specimen/Source/Method

Note

Genes Tested:  APC*; BMPR1A*; CDH1*; CTNNA1*; EPCAM**; MLH1; MSH2; MSH6; PMS2; SMAD4; STK11; TP53

*One or more exons are not covered by sequencing and/or deletion/duplication analysis for the indicated gene; see Additional Technical Information.
**Deletion/duplication analysis of EPCAM (NM_002354) exon 9 only, sequencing is not available for this gene.

Hotline History

N/A

CPT Codes

81201; 81203; 81292; 81294; 81295; 81297; 81298; 81300; 81317; 81319; 81403

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Components

Component Test Code* Component Chart Name LOINC
3005964 Spcm GASCAN
3005965 GASCAN Interp
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Lynch syndrome
  • Peutz-Jeghers syndrome
  • PJS
  • Juvenile polyposis syndrome
  • JPS
  • FAP
  • GAPPS
  • HDGC
  • Hereditary gastrointestinal cancer
  • Li-Fraumeni syndrome
  • Gastric adenocarcinoma and proximal polyposis of the stomach
  • Hereditary diffuse gastric cancer
  • Hereditary stomach cancer
  • AFAP
  • Familial adenomatous polyposis
Hereditary Gastric Cancer Panel, Sequencing and Deletion/Duplication