C5 Inhibitors Drug Monitoring Panel

3005961
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Ordering Recommendation

Use to monitor complement blockage in patients treated with C5 inhibitor drugs.

Mnemonic

C5 INH PAN

Methodology

Quantitative Turbidimetric/Quantitative Radial Immunodiffusion

Performed

Tue, Fri

Reported

1-9 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Plain red.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2.0 mL serum to an ARUP standard transport tube and freeze immediately. (Min: 2.0 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Specimens received refrigerated, ambient, lipemic specimens, or grossly hemolyzed specimens. Serum separator tubes. Specimens collected using calcium-binding anticoagulants (i.e., EDTA, ACD).

Remarks
Stability

Refer to individual components.

Reference Interval

Test Number
 Components
 Reference Interval
  Complement Activity, Total Turbidimetric 38.7-89.9 U/mL
  Complement Component 5 7-20 mg/dL
  Complement Activity, Alternative Pathway 59 percent normal or greater
  Complement C5, Functional 23.0 U/mL or greater

Interpretive Data




Component Interpretation
Complement Activity, Total Turbidimetric Low: 38.6 U/mL or less 
Normal: 38.7-89.9 U/mL 
High: 90.0 U/mL or greater
Complement C5, Functional Low: 22.9 U/mL or less
Low-Normal: 23.0-28.3 U/mL
Normal: 28.4 U/mL or greater
Complement Activity, Alternative Pathway This test is intended for screening of functional activity of the alternative pathway of the complement system. Abnormal test results can be due to hereditary absence or acquired functional defect in the activity of any of the individual components of the alternative pathway.
C5 Inhibitors Drug Monitoring Pan Interp Patients treated with C5 inhibitors may show decreased/absent activity in total complement functional assay (CH50), alternative pathway functional assay (AH50), and C5 functional assay with normal or elevated C5 protein concentrations. Normal CH50, AH50, or C5 functional activity with normal or elevated C5 protein concentrations indicate inadequate complement blockage. Serial measurements are recommended when monitoring treatment efficacy. Decreases in both C5 concentration and C5 functional activity suggests a secondary consumption process or C5 deficiency. Repeat testing using a new specimen is suggested if in vitro complement activation and consumption of components due to conditions of collection, transport, and/or handling is suspected.

Compliance Category

Standard

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/21/2023
X
N/A

CPT Codes

86160; 86161 x2; 86162

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Components

Component Test Code* Component Chart Name LOINC
0050156 Complement Component 5 4505-4
2005374 Complement Activity, Alternative Pathway 74520-8
3002576 Complement Activity, Total Turbidimetric 4532-8
3005962 Complement C5, Functional 60472-8
3006097 C5 Inhibitors Drug Monitoring Pan Interp
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • AH50
  • anti-C5
  • C5 inhibitor
  • CH50 total
  • Complement blocking
  • Complement C5
  • Complement C5 functional
  • Complement monitoring
  • concentration
  • Eculizumab
  • Ravulizumab
C5 Inhibitors Drug Monitoring Panel