CIC (19q13.2) Gene Rearrangement by FISH

3005916
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Ordering Recommendation

Use to diagnose CIC-rearranged sarcoma (CRS). This test does not identify the translocation partner.

Mnemonic

CIC FISH

Methodology

Fluorescence in situ Hybridization (FISH)

Performed

Mon-Fri

Reported

3-7 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

Tumor tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect paraffin block from excessive heat. Transport tissue block or 5 unstained (4-micron thick sections) positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at 800-522-2787 (kit recommended but not necessary). (Min. 2 slides)

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.

Remarks

Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
10/25/2022
X
N/A

CPT Codes

88366

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Components

Component Test Code* Component Chart Name LOINC
3000703 Scoring Method 81304-8
3005917 CIC FISH Reference Number
3005918 CIC FISH Source
3005919 CIC FISH Result
3005921 Total Cell Count
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 19q13.2
  • CIC FISH
  • CIC gene rearrangement
  • CIC-rearranged sarcoma (CRS)
CIC (19q13.2) Gene Rearrangement by FISH