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Trazodone, Serum/Plasma
Ordering Recommendation
Use to optimize drug therapy and monitor patient adherence.
New York DOH Approval Status
Specimen Required
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Refrigerated.
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
After separation from cells: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 4 months
Methodology
Liquid Chromatography-Tandem Mass Spectrometry
Performed
Wed
Reported
1-8 days
Reference Interval
| Test Number |
Components |
Reference Interval |
||||
|---|---|---|---|---|---|---|
| Trazodone_Serum/Plasma |
|
Interpretive Data
Trazodone is a selective serotonin reuptake inhibitor antidepressant drug indicated for the treatment of major depressive disorder. The pharmacokinetics of trazodone is influenced by drug-drug interactions that induce or inhibit CYP3A4 metabolism. Adverse effects may include sedation, fatigue, headache, blurred vision, nausea, and cardiac arrhythmia. The risk of serotonin syndrome is increased with concomitant use of other serotonergic drugs. Concomitant use of trazodone with anticoagulants and nonsteroidal anti-inflammatory drugs may increase the risk of bleeding.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA-certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
80338 (Alt code: G0480)
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3005862 | Trazodone_Serum/Plasma | 4064-2 |
Aliases
- Desyrel
- desyrel blood level
- Molipaxin
- trazodone blood level
