Ordering Recommendation

Recommended test to confirm a hereditary cause of pancreatic cancer in individuals with a personal or family history. Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.

To compare this test to other hereditary cancer panels, refer to the Hereditary Cancer Panel Comparison table.

New York DOH Approval Status

Testing is not New York state approved. Specimens from New York clients will be sent out to a New York state-approved laboratory.

Specimen Required

Patient Preparation

Lavender or pink (EDTA) or yellow (ACD solution A or B).
New York State Clients: Lavender (EDTA) or yellow (ACD solution)

Specimen Preparation

Transport 3 mL whole blood. (Min: 2 mL)
New York State Clients: Transport 10 mL whole blood (Min: 7 mL)

Storage/Transport Temperature


Unacceptable Conditions

Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue; DNA.


Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable


Massively Parallel Sequencing/Sequencing/Multiplex Ligation-Dependent Probe Amplification (MLPA)




14-21 days

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)


Genes Tested:  APC*; ATM; BRCA1*; BRCA2; CDK4; CDKN2A*; EPCAM**; MEN1*; MLH1; MSH2; MSH6; PALB2; PMS2; STK11; TP53; VHL*

*One or more exons are not covered by sequencing and/or deletion/duplication analysis for the indicated gene; see Additional Technical Information.
**Deletion/duplication analysis of EPCAM (NM_002354) exon 9 only, sequencing is not available for this gene.

Hotline History


CPT Codes

81201; 81203; 81408; 81162; 81292; 81294; 81295; 81297; 81298; 81300; 81307; 81317; 81319; 81404; 81405; 81351; 81403; 81479


Component Test Code* Component Chart Name LOINC
3005709 PANCAN Specimen 31208-2
3005710 PANCAN Interp 41103-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • AFAP
  • Familial adenomatous polyposis (FAP)
  • Familial atypical multiple mole melanoma-pancreatic carcinoma (FAMMM-PC) syndrome
  • Hereditary breast and ovarian cancer (HBOC) syndrome
  • Hereditary nonpolyposis colorectal cancer (HNPCC)
  • Li-Fraumeni syndrome (LFS)
  • Lynch syndrome
  • Multiple endocrine neoplasia type 1
  • Peutz-Jeghers syndrome (PJS)
  • Von Hippel Lindau
Hereditary Pancreatic Cancer Panel, Sequencing and Deletion/Duplication