Ordering Recommendation

Recommended test to confirm a hereditary cause of pancreatic cancer in individuals with a personal or family history. Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.

To compare this test to other hereditary cancer panels, refer to the Hereditary Cancer Panel Comparison table.

Mnemonic

PANCAN NGS

Methodology

Massively Parallel Sequencing/Sequencing/Multiplex Ligation-dependent Probe Amplification

Performed

Varies

Reported

3-6 weeks

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

Lavender or pink (EDTA) or yellow (ACD solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 2 mL)
New York State Clients: Transport 10 mL whole blood (Min: 7 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue; DNA.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Genes Tested:  APC*; ATM; BRCA1*; BRCA2; CDK4; CDKN2A*; EPCAM**; MEN1*; MLH1; MSH2; MSH6; PALB2; PMS2; STK11; TP53; VHL*

*One or more exons are not covered by sequencing and/or deletion/duplication analysis for the indicated gene; see Additional Technical Information.
**Deletion/duplication analysis of EPCAM (NM_002354) exon 9 only, sequencing is not available for this gene.

Hotline History

N/A

CPT Codes

81201; 81203; 81408; 81162; 81292; 81294; 81295; 81297; 81298; 81300; 81307; 81317; 81319; 81404; 81405; 81351; 81403; 81479

Components

Component Test Code* Component Chart Name LOINC
3005709 PANCAN Specimen 31208-2
3005710 PANCAN Interp 41103-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • AFAP
  • Familial adenomatous polyposis (FAP)
  • Familial atypical multiple mole melanoma-pancreatic carcinoma (FAMMM-PC) syndrome
  • Hereditary breast and ovarian cancer (HBOC) syndrome
  • Hereditary nonpolyposis colorectal cancer (HNPCC)
  • Li-Fraumeni syndrome (LFS)
  • Lynch syndrome
  • Multiple endocrine neoplasia type 1
  • Peutz-Jeghers syndrome (PJS)
  • Von Hippel Lindau
Hereditary Pancreatic Cancer Panel, Sequencing and Deletion/Duplication