Ordering Recommendation
Recommended test to confirm a hereditary cause of prostate cancer in individuals with a personal or family history. Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.
To compare this test to other hereditary cancer panels, refer to the Hereditary Cancer Panel Comparison table.
Mnemonic
Methodology
Massively Parallel Sequencing/Sequencing/Multiplex Ligation-dependant Probe Amplification
Performed
Varies
Reported
21-42 days
New York DOH Approval Status
Specimen Required
Lavender or pink (EDTA) or yellow (ACD solution A or B).
Transport 3 mL whole blood. (Min: 2 mL)
Refrigerated
Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue; DNA.
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable
Reference Interval
By report
Interpretive Data
Refer to report.
Laboratory Developed Test (LDT)
Note
Genes Tested: ATM; BRCA1*; BRCA2; CHEK2*; EPCAM**; HOXB13; MLH1; MSH2; MSH6; NBN; PALB2; PMS2; RAD51D; TP53
*One or more exons are not covered by sequencing and/or deletion/duplication analysis for the indicated gene; see Additional Technical Information.
**Deletion/duplication analysis of EPCAM (NM 002354) exon 9 only, sequencing is not available for this gene.
Hotline History
Hotline History
CPT Codes
81408; 81162; 81403; 81292; 81294; 81295; 81297; 81298; 81300; 81307; 81317; 81319; 81351; 81479
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
3005687 | PROCAN Specimen | 66746-9 |
3005688 | PROCAN Interp | 83006-7 |
Aliases
- BRCA
- hereditary breast and ovarian cancer (HBOC) syndrome
- Hereditary nonpolyposis colorectal cancer (HNPCC)
- Li-Fraumeni syndrome (LFS)
- Lynch syndrome