Ordering Recommendation
Use to confirm a clinical diagnosis of familial transthyretin amyloidosis (ATTR). Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For additional information, please contact an ARUP genetic counselor at 800-242-2787 ext. 2141.
Mnemonic
TTR NGS
Methodology
Massively Parallel Sequencing
Performed
Varies
Reported
14-21 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
Collect
Lavender or pink (EDTA), or yellow (ACD solution A or B).
Specimen Preparation
Transport 3 mL whole blood. (Min: 2 mL)
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Serum or plasma; grossly hemolyzed or frozen specimens; saliva, buccal brush, or swab; FFPE tissue.
Remarks
Stability
Ambient: 72 hours; Refrigerated: 2 weeks; Frozen: Unacceptable
Reference Interval
By report
Interpretive Data
Refer to report.
Compliance Category
Laboratory Developed Test (LDT)
Note
Gene Tested: TTR (NM_000371)
Hotline History
Hotline History
Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
N/A
CPT Codes
81404
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
3004532 | TTR Specimen | |
3004533 | TTR Interp |
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
- ATTR amyloid neuropathy
- ATTR amyloidosis
- ATTR cardiac amyloidosis
- ATTR leptomeningeal amyloidosis/CNS amyloidosis
- cerebral amyloid angiopathy
- familial amyloid cardiomyopathy
- familial amyloid polyneuropathy type I or type II
- familial euthyroid hyperthyroxinemia
- hATTR
- hereditary transthyretin amyloidosis
Familial Transthyretin Amyloidosis (TTR) Sequencing