3004471
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Pharmacogenetics Panel: Psychotropics

PGX PSYCH
Example Reports
Negative
Positive

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Supplemental Resources

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Informed Consent for Genetic Testing (required for NY patients)

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Additional Technical Information

Ordering Recommendation

Use to assess genetic risk of abnormal drug metabolism for drugs metabolized by ANKK1, COMT, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, DRD2, GRIK4, HTR2A, HTR2C, MTHFR, OPRM1, and UGT2B15. May aid in drug selection and dose planning for many drugs. For testing that includes access to the GeneDose database, refer to to Pharmacogenetics Panel: Psychotropics, with GeneDose Access (3006366).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Whole Blood: Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or serum. Specimens collected in sodium heparin or lithium heparin. Frozen specimens in glass collection tubes.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month

Methodology

Polymerase Chain Reaction (PCR)/Fluorescence Monitoring/Sequencing

Performed

Varies

Reported

5-10 days
If reflexed: 5-7 additional days are required for LR-PCR and sequencing.

Reference Interval

By report

Interpretive Data

Refer to report

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Compliance Category

Laboratory Developed Test (LDT)

Note

Whole blood is the preferred specimen type. Saliva samples that yield inadequate DNA quality and/or quantity will be reported as inconclusive if test performance does not meet laboratory-determined criteria for reporting. Saliva is only validated for the OpenArray and CNV portions of testing and not the long-range PCR/duplication testing. Long-range PCR/duplication testing will not be performed for saliva samples.

If long-range PCR/duplication testing is performed, additional charges apply. Approximately less than 5% of samples require 2D6 copy number determination.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
11/14/2023
X
N/A

CPT Codes

81225; 81226; 81227; 81230; 81231; 81291; 81479; if reflexed, add 81479

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Components

Component Test Code* Component Chart Name LOINC
2008769 OPRM1 Genotype, Interpretation 94415-7
2008926 CYP2D6 Phenotype 79715-9
2008931 CYP2C9 Phenotype 79716-7
2008936 CYP2C19 Phenotype 79714-2
3001504 CYP2C9 Genotype 46724-1
3001510 CYP2C19 Genotype 57132-3
3001515 CYP2D6 Genotype 40425-1
3001520 CYP3A4 Genotype 81139-8
3001521 CYP3A5 Genotype 81140-6
3004493 CYP2B6 Genotype 72882-4
3004494 CYP2B6 Phenotype 79720-9
3004504 CYP3A4 Phenotype 81145-5
3004505 CYP3A5 Phenotype 79717-5
3005486 PGX PSYCH Specimen 66746-9
3005487 UGT2B15_1902023 94418-1
3005489 ANKK1 rs1800497 94402-5
3005491 COMT rs4680 74511-7
3005493 DRD2 rs1799978 94411-6
3005495 GRIK4 rs1954787 94413-2
3005497 HTR2A rs6311 75726-0
3005498 HTR2A rs7997012 93190-7
3005500 HTR2C rs3813929 75732-8
3005502 MTHFR rs1801133 28005-7
3005503 MTHFR rs1801131 28060-2
3005505 OPRM1 Phenotype, Interpretation 81259-4
3005506 PGX PSYCH Interpretation 50398-7
3016892 EER PGX Panel: Psych 11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • ANKK1
  • COMT
  • CYP2B6
  • CYP2C19
  • CYP2C9
  • CYP2D6
  • CYP3A4
  • CYP3A5
  • Cytochrome P450
  • DRD2
  • GRIK4
  • HTR2A
  • HTR2C
  • MTHFR
  • OPRM1
  • Pharmacogenetics
  • Pharmacogenomics
  • UGT2B15
Pharmacogenetics Panel: Psychotropics