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Celiac Antibodies, Tissue Transglutaminase (tTG), IgA and IgA, Total
Copy Utility
Ordering Recommendation
Recommended single screening test to identify IgA competence and assess tTG IgA concentrations in individuals with suspected celiac disease.
Mnemonic
Methodology
Quantitative Immunoturbidimetry/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1.5 mL)
Refrigerated.
Plasma. Contaminated, hemolyzed, grossly icteric or grossly lipemic specimens.
After separation from cells: Ambient: Unacceptable; Refrigerated: 14 days; Frozen: 6 months (avoid repeated freeze/thaw cycles)
Reference Interval
| Test Number |
Components |
Reference Interval |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Immunoglobulin A |
|
|||||||||||||||
| Tissue Transglutaminase (tTG) Ab, IgA | 0-3 U/mL |
Interpretive Data
Refer to report.
| Component | Interpretive Data |
|---|---|
| Tissue Transglutaminase Antibody, IgA | 3 U/mL or less: Negative 4-10 U/mL: Weak Positive 11 U/mL or greater: Positive |
FDA
Note
This is not a reflex test. Test 2008114, Celiac Disease Reflexive Cascade is the preferred reflex screening test for Celiac Disease.
Hotline History
Hotline History
CPT Codes
82784; 86364
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050340 | Immunoglobulin A | 2458-8 |
| 0097709 | Tissue Transglutaminase (tTG) Ab, IgA | 46128-5 |
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