Ordering Recommendation

Use to assess genetic risk of abnormal drug metabolism for CYP2B6 substrates. May aid in drug selection and dose planning for drugs metabolized by CYP2B6.

Mnemonic

2B6GENO

Methodology

Polymerase Chain Reaction/Fluorescence Monitoring

Performed

Varies

Reported

5-10 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA), Pink (K2EDTA), or Yellow (ACD Solution A or B).

Specimen Preparation

Transport 3 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or serum. Specimens collected in sodium heparin or lithium heparin.

Remarks
Stability

Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Laboratory Developed Test (LDT)

Note

Whole blood is the preferred specimen. Saliva samples that yield inadequate DNA quality and/or quantity will be reported as inconclusive if test performance does not meet laboratory-determined criteria for reporting.

Hotline History

N/A

CPT Codes

81479

Components

Component Test Code* Component Chart Name LOINC
3004492 2B6 Specimen 66746-9
3004493 CYP2B6 Genotype 72882-4
3004494 CYP2B6 Phenotype 79720-9
3004495 2B6 Interpretation 77202-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 2B6
  • bupropion
  • CYP2B6
  • Cytochrome P450 2B6
  • efavirenz
  • methadone
  • nevirapine
CYP2B6