Microsatellite Instability (MSI) HNPCC/Lynch Syndrome by PCR
Screening test for Lynch syndrome. Use to determine potential eligibility for immunotherapy by identifying microsatellite instability-high (MSI-H) cancers.
New York DOH Approval Status
Tumor AND normal epithelial tissue.
Tissue: Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue block(s) or 10 unstained 5-micron slides (5 tumor and 5 normal epithelial). Transport block(s) and/or slide(s) in a tissue transport kit (ARUP Supply #47808) available online through eSupply using ARUP Connect or contact ARUP Client Services at 800-522-2787.
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months
Less than 25 percent tumor or less than 50 percent normal epithelial tissue. Specimens fixed/processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). Decalcified specimens.
Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Capillary Electrophoresis/Polymerase Chain Reaction (PCR)
Refer to report.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|0051741||Microsatellite Marker BAT-25||81697-5|
|0051742||Microsatellite Marker BAT-26||81698-3|
|0051743||Microsatellite Marker MONO-27||81701-5|
|0051745||Microsatellite Marker NR-21||81699-1|
|0051746||Microsatellite Marker NR-24||81700-7|
|2001370||Microsatellite Instability Specimen||31208-2|
- BAT -25, BAT-26, MON-27, NR-21, NR-24 genotypes
- HNPCC MSI
- HNPCC tumor screening
- Lynch Syndrome MSI
- Lynch syndrome tumor screening
- microsatellite instability
- MSI Lynch syndrome