Screening test for Lynch syndrome. Use to determine potential eligibility for immunotherapy by identifying microsatellite instability-high (MSI-H) cancers.
DNA isolation: Sun-Sat
New York DOH Approval Status
Tumor AND normal epithelial tissue.
Tissue: Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue block(s) or 10 unstained 5-micron slides (5 tumor and 5 normal epithelial). (Min: 3 tumor tissue and 3 normal epithelial tissue slides) Transport block(s) and/or slide(s) in a tissue transport kit (ARUP Supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months
Extracted DNA: Refrigerated.
Less than 25 percent tumor or less than 50 percent normal epithelial tissue. DNA extracted by a non-CLIA lab. DNA extracted without a corresponding circled H&E slide. Specimens fixed/processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). Decalcified specimens.
Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Extracted DNA: Ambient: 1 month; Refrigerated: Indefinitely; Frozen: Indefinitely
Refer to report.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|0051741||Microsatellite Marker BAT-25|
|0051742||Microsatellite Marker BAT-26|
|0051743||Microsatellite Marker MONO-27|
|0051745||Microsatellite Marker NR-21|
|0051746||Microsatellite Marker NR-24|
|2001370||Microsatellite Instability Specimen||31208-2|
- BAT -25, BAT-26, MON-27, NR-21, NR-24 genotypes
- HNPCC MSI
- HNPCC tumor screening
- Lynch Syndrome MSI
- Lynch syndrome tumor screening
- microsatellite instability
- MSI Lynch syndrome