Microsatellite Instability (MSI) HNPCC/Lynch Syndrome by PCR

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Stable
Unstable

Ordering Recommendation

Screening test for Lynch syndrome. Use to determine potential eligibility for immunotherapy by identifying microsatellite instability-high (MSI-H) cancers.

Mnemonic

MSIPCR

Methodology

Capillary Electrophoresis

Performed

Varies

Reported

10-20 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Tumor AND normal epithelial tissue.

Specimen Preparation

Tissue: Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue block(s) or 10 unstained 5-micron slides (5 tumor and 5 normal epithelial). (Min: 3 tumor tissue and 3 normal epithelial tissue slides) Transport block(s) and/or slide(s) in a tissue transport kit (ARUP Supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months

Unacceptable Conditions

Less than 25 percent tumor or less than 50 percent normal epithelial tissue. Specimens fixed/processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). Decalcified specimens.

Remarks

Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval

Interpretive Data

Refer to report.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA-certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/21/2023
X
11/14/2022
X
11/15/2021
X
N/A

CPT Codes

81301

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Components

Component Test Code* Component Chart Name LOINC
0051741 Microsatellite Marker BAT-25
0051742 Microsatellite Marker BAT-26
0051743 Microsatellite Marker MONO-27
0051744 Microsatellite Interpretation 43368-0
0051745 Microsatellite Marker NR-21
0051746 Microsatellite Marker NR-24
2001370 Microsatellite Instability Specimen 31208-2
2002148 Block ID 57723-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • BAT -25, BAT-26, MON-27, NR-21, NR-24 genotypes
  • HNPCC MSI
  • HNPCC tumor screening
  • Lynch Syndrome MSI
  • Lynch syndrome tumor screening
  • microsatellite instability
  • MSI
  • MSI Lynch syndrome
Microsatellite Instability (MSI) HNPCC/Lynch Syndrome by PCR