Ordering Recommendation

Use to measure rivaroxaban concentration.


Chromogenic Assay




1-8 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transport 2 mL platelet-poor plasma. (Min: 1 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when additional tests are ordered

Unacceptable Conditions

Serum. EDTA, oxalate, heparin, or plasma separator tubes, hemolyzed specimens.


This test cannot be used to quantitate anticoagulants other than Rivaroxaban. This includes but is not limited to Unfractionated Heparin, Low Molecular Weight Heparin, Apixaban (Eliquis), Edoxaban (Savaysa), and Fondaparinux (Arixtra).


After separation from cells: Ambient: 4 hours; Refrigerated: Unacceptable; Frozen: 1 month

Reference Interval

Not established

Interpretive Data

When 20 mg rivaroxaban was administered daily for treatment of DVT and PE, rivaroxaban steady state levels were as follows:
Peak: 189-419 ng/mL
Trough: 6-87 ng/mL
The lower limit of detection for this assay is 25 ng/mL.
For additional information, please refer to For additional information, please refer to www.arupconsult.com

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
3004095 Rivaroxaban 74871-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Direct oral anti coagulant
  • Direct oral anti-coagulant
  • Direct oral anticoagulant
  • doac
  • Xarelto
Rivaroxaban Level