Ordering Recommendation

Use to measure edoxaban concentration.

Mnemonic

EDOX

Methodology

Chromogenic Assay

Performed

Tuesday

Reported

1-8 days

New York DOH Approval Status

Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.

Specimen Required

Patient Preparation
Collect

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transport 2 mL platelet-poor plasma. (Min: 1 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when additional tests are ordered.

Unacceptable Conditions

Serum. EDTA, oxalate, heparin, or plasma separator tubes, hemolyzed specimens.

Remarks

This test cannot be used to quantitate anticoagulants other than Edoxaban. This includes but is not limited to Unfractionated Heparin, Low Molecular Weight Heparin, Apixaban (Eliquis), Rivaroxaban (Xarelto), and Fondaparinux (Arixtra).

Stability

After separation from cells: Ambient: 4 hours; Refrigerated: Unacceptable; Frozen: 1 month

Reference Interval

Not established

Interpretive Data

When 60 mg edoxaban was administered daily for treatment of DVT and PE, edoxaban steady state levels were as follows:
Peak: 149-317 ng/mL
Trough: 10-39 ng/mL
The lower limit of detection for this assay is 20 ng/mL.
For additional information, please refer to www.arupconsult.com

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

80299

Components

Component Test Code* Component Chart Name LOINC
3004093 Edoxaban 95128-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Savaysa
Edoxaban Level