Ordering Recommendation

Use to measure apixaban concentration.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transport 2 mL platelet-poor plasma. (Min: 1 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when additional tests are ordered.

Unacceptable Conditions

Serum. EDTA, oxalate, heparin, or plasma separator tubes, hemolyzed specimens.


This test cannot be used to quantitate anticoagulants other than Apixaban. This includes but is not limited to Unfractionated Heparin, Low Molecular Weight Heparin, Rivaroxaban (Xarelto), Edoxaban (Savaysa), and Fondaparinux (Arixtra).


After separation from cells: Ambient: 4 hours; Refrigerated: Unacceptable; Frozen: 1 month
New York State Clients: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 42 days


Chromogenic Assay




1-8 days

Reference Interval

Not established

Interpretive Data

When 5 mg apixaban was administered twice daily for treatment of DVT and PE, apixaban steady state levels were as follows:
Peak: 59-302 ng/mL
Trough: 22-177 ng/mL
The lower limit of detection for this assay is 23 ng/mL.
For additional information, please refer to www.arupconsult.com

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
3004091 Apixaban 74214-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Direct oral anti coagulant
  • Direct oral anti-coagulant
  • Direct oral anticoagulant
  • doac
  • Eliquis
Apixaban Level