3004075
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FGFR1 Gene Amplification by FISH

FGFR1_FISH
Example Reports
Amplified
Not Amplified

Ordering Recommendation

Use to screen for FGFR1 gene amplification. Aids in prognostication and therapeutic decision-making for neoplasms in which amplification has been demonstrated

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Tumor tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin embed tumor tissue. Transport tissue block or 4 unstained, consecutively cut, 5-micron thick sections, mounted on positively charged glass slides. (Min: 4 slides) Protect paraffin block and/or slides from excessive heat.

Storage/Transport Temperature
Unacceptable Conditions

Paraffin block with no tumor tissue remaining. Specimens fixed in any fixative other than 10 percent neutral buffered formalin. Decalcified specimens.

Remarks

Include surgical pathology report with reason for referral. The laboratory will not reject specimens that arrive without a pathology report but will hold the specimen until this information is received.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Methodology

Fluorescence in situ Hybridization (FISH)

Performed

Varies

Reported

3-7 days

Reference Interval

By report

Interpretive Data

Refer to report.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

88366

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Components

Component Test Code* Component Chart Name LOINC
3000703 Scoring Method 81304-8
3004076 FGFR1/CEP8 FISH Ratio
3004077 Average FGFR1 Signal Number per Cell
3004078 Average CEP8 Signal Number per Cell
3004079 FGFR1 FISH Result 78916-4
3004081 FGFR1 CELLCOUNT 78917-2
3004082 FGFR1 FISH Reference Number 80398-1
3004083 FGFR1 FISH Source
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

FGFR1 Gene Amplification by FISH