Ordering Recommendation

Comprehensive panel for the evaluation of paraneoplastic and neuromuscular junction disorders, and/or encephalitis, in the presence or absence of malignancy.

Mnemonic

NEURO R3

Methodology

Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot/Quantitative Radioimmunoassay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Tue

Reported

3-10 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST)

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer three 1 mL serum aliquots to ARUP Standard Transport Tubes. (Min: 0.5 mL/aliquot)

Storage/Transport Temperature

Frozen

Unacceptable Conditions

Amniotic fluid, ocular fluid, peritoneal fluid, synovial fluid, CSF, or plasma. Contaminated, hemolyzed, icteric, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
Components
Reference Interval
2004221 N-methyl-D-Aspartate Receptor Antibody, IgG, Serum with Reflex to Titer Less than 1:10
2001771 Glutamic Acid Decarboxylase Antibody 0.0-5.0 IU/mL
2013956 CV2.1 Screen by IFA with Reflex to Titer Less than 1:10
2004890 Voltage-Gated Potassium Channel (VGKC) Antibody, Serum
Negative 31 pmol/L or less
Indeterminate 32-87 pmol/L
Positive 88 pmol/L or greater

2007961 PCCA/ANNA by IFA with Reflex to Titer and Immunoblot Effective August 17, 2020
Test Number
Components
Reference Interval
Purkinje Cell/Neuronal Nuclear IgG Scrn None Detected
Neuronal Nuclear Antibody (ANNA) IFA Titer, IgG Less than 1:10
Purkinje Cell Antibody, Titer Less than 1:10
3002917 Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot, Serum Refer to report

2008893 Amphiphysin Antibody, IgG Negative
2013320 Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer, Serum Less than 1:10
2009456 Leucine-Rich, Glioma-Inactivated Protein 1 Antibody, IgG with Reflex to Titer, Serum Less than 1:10
2009452 Contactin-Associated Protein-2 Antibody, IgG with Reflex to Titer, Serum Less than 1:10
0080009 Acetylcholine Receptor Binding Antibody
Negative 0.0-0.4 nmol/L
Positive 0.5 nmol/L or greater

3001260 Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody, IgG by IFA with Reflex to Titer, Serum Less than 1:10
3001270 Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by IFA with Reflex to Titer, Serum Less than 1:10
3001277 Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by IFA with Reflex to Titer, Serum Less than 1:10
3002885 SOX1 Antibody, IgG by Immunoblot, Serum Negative

Interpretive Data

Refer to Report

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

If N-methyl-D-Aspartate Receptor Antibody is positive, then titer will be performed. Additional charges apply.
If CV2.1 Antibody IgG Screen by IFA is positive, then titer will be performed. Additional charges apply.
If Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then titer will be performed. Additional charges apply.
Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be performed. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot will be performed. Additional charges apply.
If Leucine-Rich, Glioma-Inactivated Protein 1 Antibody, IgG with Reflex to Titer, Serum is positive, then Leucine-Rich, Glioma-Inactivated Protein 1 Antibody Titer, IgG by IFA, Serum will be performed. Additional charges apply.
If Contactin-Associated Protein-2 Antibody, IgG with Reflex to Titer, Serum is positive, then Contactin-Associated Protein-2 Antibody Titer, IgG by IFA, Serum will be performed. Additional charges apply.
If Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then an Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody Titer, IgG, Serum will be performed. Additional charges apply.
If Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then a Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody Titer, IgG, Serum will be performed. Additional charges apply.
If Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then a Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Titer, IgG will be performed. Additional charges apply.

Hotline History

N/A

CPT Codes

83519 x2; 84182 x2; 86255 x9; 86341; if reflexed, additional CPT codes may apply: 86256; 84182 x4

Components

Component Test Code* Component Chart Name LOINC
0051709 Neuronal Antibody (Amphiphysin) 94385-2
0080009 Acetylcholine Binding Antibody 11034-6
2001772 Glutamic Acid Decarboxylase Antibody 56540-8
2004222 N-methyl-D-Aspartate Receptor Ab, Serum 80221-5
2004890 Voltage-Gated Potassium Channel Ab, Ser 41871-5
2007962 Purkinje Cell/Neuronal Nuclear IgG Scrn 61177-2
2009453 CASPR2 Ab IgG Screen by IFA, Serum 82979-6
2009457 LGI1 Ab IgG Screen by IFA, Serum 82978-8
2013322 Neuromyelitis Optica/AQP4-IgG, Serum 63439-4
2013959 CV2.1 Antibody IgG Screen by IFA 72504-4
3001261 AMPA Receptor Ab IgG Screen, Serum 82733-7
3001271 GABA-B Receptor Ab IgG Screen, Serum 93428-1
3001278 MOG Antibody IgG Screen, Serum 91545-4
3002903 SOX1 Antibody, IgG by Immunoblot, Serum 82444-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Autoimmune Neurologic Disease Reflexive Panel, Serum