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Autoimmune Neurologic Disease Reflexive Panel, Serum
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Ordering Recommendation
Comprehensive panel for the evaluation of paraneoplastic and neuromuscular junction disorders, and/or encephalitis, in the presence or absence of malignancy.
Mnemonic
Methodology
Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot/Quantitative Radioimmunoassay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Tue
Reported
3-10 days
New York DOH Approval Status
Specimen Required
Serum Separator Tube (SST)
Separate from cells ASAP or within 2 hours of collection. Transfer three 1 mL serum aliquots to ARUP Standard Transport Tubes. (Min: 0.5 mL/aliquot)
Frozen
Amniotic fluid, ocular fluid, peritoneal fluid, synovial fluid, CSF, or plasma. Contaminated, hemolyzed, icteric, or lipemic specimens.
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (avoid repeated freeze/thaw cycles)
Reference Interval
| Test Number |
Components |
Reference Interval |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2004221 | N-methyl-D-Aspartate Receptor Antibody, IgG, Serum with Reflex to Titer | Less than 1:10 | |||||||||||||||
| 2001771 | Glutamic Acid Decarboxylase Antibody | 0.0-5.0 IU/mL | |||||||||||||||
| 2013956 | CV2.1 Screen by IFA with Reflex to Titer | Less than 1:10 | |||||||||||||||
| 2004890 | Voltage-Gated Potassium Channel (VGKC) Antibody, Serum |
|
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| 2007961 | PCCA/ANNA by IFA with Reflex to Titer and Immunoblot | Effective August 17, 2020
|
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| 2008893 | Amphiphysin Antibody, IgG | Negative | |||||||||||||||
| 2013320 | Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer, Serum | Less than 1:10 | |||||||||||||||
| 2009456 | Leucine-Rich, Glioma-Inactivated Protein 1 Antibody, IgG with Reflex to Titer, Serum | Less than 1:10 | |||||||||||||||
| 2009452 | Contactin-Associated Protein-2 Antibody, IgG with Reflex to Titer, Serum | Less than 1:10 | |||||||||||||||
| 0080009 | Acetylcholine Receptor Binding Antibody |
|
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| 3001260 | Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody, IgG by IFA with Reflex to Titer, Serum | Less than 1:10 | |||||||||||||||
| 3001270 | Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by IFA with Reflex to Titer, Serum | Less than 1:10 | |||||||||||||||
| 3001277 | Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by IFA with Reflex to Titer, Serum | Less than 1:10 | |||||||||||||||
| 3002885 | SOX1 Antibody, IgG by Immunoblot, Serum | Negative |
Interpretive Data
Refer to Report
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
If N-methyl-D-Aspartate Receptor Antibody is positive, then titer will be performed. Additional charges apply.
If CV2.1 Antibody IgG Screen by IFA is positive, then titer will be performed. Additional charges apply.
If Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then titer will be performed. Additional charges apply.
Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot will be performed. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot will be performed. Additional charges apply.
If Leucine-Rich, Glioma-Inactivated Protein 1 Antibody, IgG with Reflex to Titer, Serum is positive, then Leucine-Rich, Glioma-Inactivated Protein 1 Antibody Titer, IgG by IFA, Serum will be performed. Additional charges apply.
If Contactin-Associated Protein-2 Antibody, IgG with Reflex to Titer, Serum is positive, then Contactin-Associated Protein-2 Antibody Titer, IgG by IFA, Serum will be performed. Additional charges apply.
If Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then an Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antibody Titer, IgG, Serum will be performed. Additional charges apply.
If Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then a Gamma Aminobutyric Acid Receptor, Type B (GABA-BR) Antibody Titer, IgG, Serum will be performed. Additional charges apply.
If Myelin Oligodendrocyte Glycoprotein (MOG) Antibody, IgG by IFA with Reflex to Titer, Serum is positive, then a Myelin Oligodendrocyte Glycoprotein (MOG) Antibody Titer, IgG will be performed. Additional charges apply.
Hotline History
Hotline History
CPT Codes
83519 x2; 84182 x2; 86255 x9; 86341; if reflexed, additional CPT codes may apply: 86256; 84182 x4
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0051709 | Neuronal Antibody (Amphiphysin) | 94385-2 |
| 0080009 | Acetylcholine Binding Antibody | 11034-6 |
| 2001772 | Glutamic Acid Decarboxylase Antibody | 56540-8 |
| 2004222 | N-methyl-D-Aspartate Receptor Ab, Serum | 80221-5 |
| 2004890 | Voltage-Gated Potassium Channel Ab, Ser | 41871-5 |
| 2007962 | Purkinje Cell/Neuronal Nuclear IgG Scrn | 61177-2 |
| 2009453 | CASPR2 Ab IgG Screen by IFA, Serum | 82979-6 |
| 2009457 | LGI1 Ab IgG Screen by IFA, Serum | 82978-8 |
| 2013322 | Neuromyelitis Optica/AQP4-IgG, Serum | 63439-4 |
| 2013959 | CV2.1 Antibody IgG Screen by IFA | 72504-4 |
| 3001261 | AMPA Receptor Ab IgG Screen, Serum | 82733-7 |
| 3001271 | GABA-B Receptor Ab IgG Screen, Serum | 93428-1 |
| 3001278 | MOG Antibody IgG Screen, Serum | 91545-4 |
| 3002903 | SOX1 Antibody, IgG by Immunoblot, Serum | 82444-1 |
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