Ordering Recommendation

Use to evaluate response failure to vedolizumab therapy. Use to adjust dosage.

Mnemonic

VEDOL AB

Methodology

Quantitative Liquid Chromatography/Mass Spectrometry (LC-MS/MS) /Electrochemiluminescent Immunoassay

Performed

Varies

Reported

7-17 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

12 hours prior to specimen collection discontinue multivitamins or dietary supplements containing biotin (vitamin B7), commonly found in hair, skin, and nail supplements. Nivolumab (Opdivo) must be discontinued at least 4 weeks prior to testing.

Collect

Plain red. Also acceptable: Serum separator tube (SST). Collect immediately before next scheduled dose (trough specimen).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.75 mL)
Test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.

Storage/Transport Temperature

Refrigerated. Also acceptable: Frozen.

Unacceptable Conditions
Remarks
Stability

Ambient: Unacceptable; Refrigerated: 28 days; Frozen: 28 days

Reference Interval

By Report

Interpretive Data



Compliance Category

Note

Hotline History

N/A

CPT Codes

80280; 82397

Components

Component Test Code* Component Chart Name LOINC
3003677 Vedolizumab Quantitation, Serum 90805-3
3003678 Vedolizumab Antibodies, Serum 86899-2
3003679 Vedolizumab Interpretation 59462-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Vedolizumab Quantitation with Antibodies, Serum

Mayo Clinic Laboratories