Ordering Recommendation

Use to quantify kappa and lambda light chains in paraffin tissue. Does not include interpretation.

Mnemonic
SO KLP ISH
Methodology

In situ hybridization (ISH)

Performed

Mon-Fri

Reported

2-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Tissue or cells.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin-embed specimen (cells must be prepared into a cellblock). Protect paraffin block and/or slides from excessive heat. Transport tissue block or 8 unstained (3- to 5-micron thick sections), positively-charged slides in a tissue transport kit (ARUP supply #47808). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 4 slides). If sending precut slides, do not oven bake.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Unacceptable Conditions: Specimens submitted with non-representative tissue type. Depleted specimens.

Remarks

IMMUNOHISTOCHEMISTRY ORDERING AND SUBMISSION DETAILS: Submit electronic request. If you do not have electronic ordering capability, use an ARUP Immunohistochemistry Stain Form (#32978) with an ARUP client number. For additional technical details, contact ARUP Client Services at (800) 522-2787.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval
Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

88368; 88369

Components
Component Test Code* Component Chart Name LOINC
3003592 Kappa by ISH
3003593 Lambda by ISH
3003594 Kappa/Lambda ISH Reference Number
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
Kappa/Lambda Light Chain Panel by In Situ Hybridization Stain Only