Mucopolysaccharidoses Type 4A/6 Total Chondroitin Sulfate and Dermatan Sulfate with NRE (Sensi-Pro®) Quantitative, Serum
Ordering Recommendation
Aids in the diagnosis and monitoring of patients with MPS Type 4A or Type 6.
Mnemonic
Methodology
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Performed
Varies
Reported
2-3 weeks
New York DOH Approval Status
Specimen Required
Serum (Serum Separator Tube (SST)).
Transfer 500 µL serum to ARUP Standard transport Tube and freeze immediately. (Min 300 µL)
Frozen
Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 4 month (3 freeze thaw cycles are acceptable)
Reference Interval
By report
Interpretive Data
Total Chondroitin Sulfate (CS) and Dermatan Sulfate (DS), Serum is a sum of the internal disaccharides D0a0, D0a4, and D0a6.
NRE = Non Reducing End
This test was developed, and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
Hotline History
CPT Codes
83864
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
3003488 | MPS 4A/6, Serum Interpretation | 59462-2 |
3003492 | Chondroitin and Dermatan Sulfate, Serum | |
3003493 | a4 (MPS 6 NRE), Serum | |
3003494 | a6 (MPS 4A NRE), Serum | |
3003495 | a4/a6 Ratio, Serum |
Aliases
- CS non reducing end assay
- DS non reducing end assay
- MPS 4a
- MPS 6
- MPS type 4a
- MPS type 6
- Mucopolysaccharides
- Total Chondroitin Sulfate
- Total Dermatan Sulfate