Ordering Recommendation

Primarily for research and to support attempts to understand the pathogenesis of immune, infectious, allergic, or inflammatory disorders.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

CSF.

Specimen Preparation

Transfer 1 mL CSF to an ARUP Standard Transport Tube. (Min: 0.4 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Additional specimens must be submitted when multiple tests are ordered. Ship in an ARUP Standard Transport Tube.

Unacceptable Conditions

Refrigerated specimens. Contaminated or heat inactivated specimens.

Remarks
Stability

Ambient: 30 minutes; Refrigerated: Unacceptable; Frozen: 1 month

Methodology

Quantitative Multiplex Bead Assay

Performed

Sun-Sat

Reported

1-4 days

Reference Interval

Test Number
Components
Reference Interval
  Interleukin 2 Receptor, Soluble, CSF 26.8 pg/mL or less
  Interleukin 12, CSF 1.9 pg/mL or less
  Interferon gamma, CSF 4.2 pg/mL or less
  Interleukin 4, CSF 5.2 pg/mL or less
  Interleukin 5, CSF 2.1 pg/mL or less
  Interleukin 10, CSF 12.7 pg/mL or less
  Interleukin 13, CSF 7.3 pg/mL or less
  Interleukin 1 beta, CSF 6.5 pg/mL or less
  Interleukin 6, CSF 7.5 pg/mL or less
  Interleukin 8, CSF 4.6 - 283.5 pg/mL
  Tumor Necrosis Factor - alpha, CSF 1.7 pg/mL or less
  Interleukin 2, CSF 2.1 pg/mL or less
  Interleukin 17, CSF 4.6 pg/mL or less

Interpretive Data

Results are used to understand the pathophysiology of immune, infectious, or inflammatory disorders, or may be used for research purposes.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Cytokine levels may demonstrate diurnal variation. For longitudinal comparison, it is recommended that cytokine levels be determined at the same time of day.

Hotline History

N/A

CPT Codes

83520 x12; 83529

Components

Component Test Code* Component Chart Name LOINC
3003314 Interferon gamma, CSF 99764-3
3003315 Interleukin 10, CSF 49909-5
3003316 Interleukin 12, CSF 99765-0
3003317 Interleukin 13, CSF 70089-8
3003318 Interleukin 17, CSF 99766-8
3003319 Interleukin 1 beta, CSF 99767-6
3003320 Interleukin 2, CSF 70077-3
3003321 Interleukin 2 Receptor, Soluble, CSF 99768-4
3003322 Interleukin 4, CSF 70083-1
3003323 Interleukin 5, CSF 70084-9
3003324 Interleukin 6, CSF 49919-4
3003325 Interleukin 8, CSF 99769-2
3003326 Tumor Necrosis Factor - alpha, CSF
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • cytokine
  • Cytokine 12
  • cytokines
  • IFN
  • IFN G
  • IFN Gamma
  • IL
  • IL 0
  • IL 1
  • IL 1 B
  • IL 10
  • IL 12
  • IL 13
  • IL 17
  • IL 1B
  • IL 2
  • IL 2 R
  • IL 2R
  • IL 4
  • IL 5
  • IL 6
  • IL 8
  • IL-1 Beta
  • IL-10
  • IL-12
  • IL-13
  • IL-2
  • IL-2R
  • IL-4
  • IL-5
  • IL-6
  • IL-8
  • IL1
  • IL1 B
  • IL1 Beta
  • IL10
  • IL12
  • IL13
  • IL17
  • IL2
  • IL2 R
  • IL2 Receptor
  • IL2R
  • IL4
  • IL5
  • IL6
  • IL8
  • Tumor Necrosis Factor alpha
Cytokine Panel 13, CSF