Ordering Recommendation

Use to optimize drug therapy and monitor patient adherence.

Mnemonic

CHLORP SP

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Mon

Reported

Within 8 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Timing of specimen collection: Predose (trough) draw - At steady state concentration.

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA), pink (K2EDTA), green (Heparin) or gray (Potassium oxalate or Sodium fluoride).

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Whole blood. Hemolyzed specimens. Gel separator tubes, light blue (citrate) or yellow (SPS or ACD solution).

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 14 days; Frozen: 14 days

Reference Interval

Therapeutic Range 30-300 ng/mL
Toxic Level Greater than or equal to 600 ng/mL

Interpretive Data

Chlorpromazine is a neuroleptic drug indicated for the treatment of schizophrenia, psychotic disorders and intractable hiccup. Chlorpromazine should not be used in patients who have epilepsy, Parkinson's disease, hypoparathyroidism, myasthenia gravis, and prostatic hypertrophy. Adverse effects may include drowsiness, hypotension, agranulocytosis, cardiac abnormalities, seizures and rare life-threatening effects, such as phenothiazine sudden death syndrome, and neuroleptic malignant syndrome.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

80342 (Alt code: G0480)

Components

Component Test Code* Component Chart Name LOINC
3003037 Chlorpromazine, Serum_Plasma 3471-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Largactil
  • Ormazine
  • Thorazine
  • Thorazine Spansule
Chlorpromazine, Serum or Plasma