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Chlorpromazine, Serum or Plasma
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Ordering Recommendation
Use to optimize drug therapy and monitor patient adherence.
Mnemonic
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Mon
Reported
1-8 days
New York DOH Approval Status
Specimen Required
Timing of specimen collection: Predose (trough) draw - At steady state concentration.
Plain red. Also acceptable: Lavender (K2 or K3EDTA), pink (K2EDTA), green (Heparin) or gray (Potassium oxalate or Sodium fluoride).
Separate serum or plasma from cells within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Frozen.
Whole blood. Hemolyzed specimens. Gel separator tubes, light blue (citrate) or yellow (SPS or ACD solution).
After separation from cells: Ambient: Unacceptable; Refrigerated: 14 days; Frozen: 14 days
Reference Interval
| Therapeutic Range | 30-300 ng/mL |
| Toxic Level | Greater than or equal to 600 ng/mL |
Interpretive Data
Chlorpromazine is a neuroleptic drug indicated for the treatment of schizophrenia, psychotic disorders and intractable hiccup. Chlorpromazine should not be used in patients who have epilepsy, Parkinson's disease, hypoparathyroidism, myasthenia gravis, and prostatic hypertrophy. Adverse effects may include drowsiness, hypotension, agranulocytosis, cardiac abnormalities, seizures and rare life-threatening effects, such as phenothiazine sudden death syndrome, and neuroleptic malignant syndrome.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
80342 (Alt code: G0480)
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3003037 | Chlorpromazine, Serum_Plasma | 3471-0 |
Aliases
- Largactil
- Ormazine
- Thorazine
- Thorazine Spansule
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