Acceptable reflexive panel for the differential diagnosis of acquired neuromuscular junction disorders. Panel includes acetylcholine receptor binding, blocking, and modulating antibodies; ganglionic acetylcholine receptor antibodies; P/Q-type and N-type voltage-gated calcium channels; voltage-gated potassium channels; titin antibody; striated muscle antibodies; and leucine-rich glioma-inactivated protein 1 antibody and contactin-associated protein-2 antibody IgG with reflex to titers.
Quantitative Radioimmunoassay/Qualitative Radiobinding Assay/Semi-Quantitative Flow Cytometry/Semi-Quantitative Indirect Fluorescent Antibody
Refer to individual components
New York DOH Approval Status
Serum separator tube (SST).
Separate serum from cells ASAP or within 2 hours of collection. Transport 2 mL serum. (Min: 1 mL)
Plasma. Contaminated, hemolyzed, or severely lipemic specimens.
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
|0080009||Acetylcholine Receptor Binding Antibody||
|0099580||Acetylcholine Receptor Blocking Antibody||Effective November 18, 2013
|0099521||Acetylcholine Receptor Modulating Antibody||Effective August 20, 2012
|0092628||P/Q-Type Voltage-Gated Calcium Channel (VGCC) Antibody||Effective November 14, 2011
|N-Type Calcium Channel Antibody||
|3003020||Ganglionic Acetylcholine Receptor Antibody||
|2004890||Voltage-Gated Potassium Channel (VGKC) Antibody, Serum||
|2005636||Titin Antibody||Effective January 17, 2012
|0050746||Striated Muscle Antibodies, IgG with Reflex to Titer||Less than 1:40|
|2009456||Leucine-Rich, Glioma-Inactivated Protein 1 Antibody, IgG with Reflex to Titer, Serum||Less than 1:10|
|2009452||Contactin-Associated Protein-2 Antibody, IgG with Reflex to Titer, Serum||Less than 1:10|
Refer to report.
Laboratory Developed Test (LDT)
If Acetylcholine Receptor Binding Antibody result is greater than 0.4 nmol/L or Acetylcholine Receptor Blocking Antibody result is greater than 26 percent, then Acetylcholine Receptor Modulating Antibody will be added. If Striated Muscle Ab is detected, then a titer will be added. If VGKC is Indeterminate or Positive, LGI1 Antibody IgG and CASPR2 Antibody IgG will be added. If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. If CASPR2 antibody IgG is positive, then CASPR2 antibody IgG titer will be added. Additional charges apply.
83519 x5; 83516 x2; 86255; if reflexed, add 83516 and/or 86256 and/or 86255x2, if further reflexed add 86256 per titer
|Component Test Code*||Component Chart Name||LOINC|
|0050747||Striated Muscle Antibodies, IgG Screen||49692-7|
|0080009||Acetylcholine Binding Antibody||11034-6|
|0092629||P/Q-Type Calcium Channel Antibody||33980-4|
|0099580||Acetylcholine Blocking Antibody||42937-3|
|2004890||Voltage-Gated Potassium Channel Ab, Ser||41871-5|
|3002047||N-Type Calcium Channel Antibody||33979-6|
|3003019||Ganglionic Acetylcholine Receptor Ab||42233-7|