Ordering Recommendation

Preferred panel to evaluate viral etiology in patients with acute hepatitis. Not recommended for screening asymptomatic patients. Panel includes HAV IgM, HBV core antibody IgM, HBV surface antigen, HCV antibody with reflex to HCV by quantitative NAAT.

Mnemonic

HEPACUTEQR

Methodology

Qualitative Chemiluminescent Immunoassay/Quantitative Transcription Mediated Amplification

Performed

Sun-Sat

Reported

1-2 days
If reflexed, add 1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube (SST) or Pink (K2EDTA).

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 2.0 mL) Also acceptable: K2EDTA plasma.

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Heparinized plasma. Specimens containing particulate material. Heat-inactivated, severely hemolyzed, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 5 days; Frozen: 2 months (avoid freeze/thaw cycles)

Reference Interval

Test Number
Components
Reference Interval
0020093 Hepatitis A Virus Antibody, IgM Negative
0020092 Hepatitis B Virus Core Antibody, IgM Negative
0020089 Hepatitis B Virus Surface Antigen with Reflex to Confirmation
Test Number
Components
Reference Interval
Hepatitis B Virus Surface Antigen Negative
0020128 Hepatitis B Virus Surface Antigen, Confirmation Refer to report

2010784 Hepatitis C Virus Antibody by CIA with Reflex to HCV by Quantitative NAAT
Available Separately
Components
Reference Interval
2002483 Hepatitis C Virus Antibody by CIA Negative
Hepatitis C Antibody by CIA Index 0.79 IV or less Negative
0.80 to 0.99 IV Equivocal
1.00 to 10.99 IV Low Positive
11.00 IV or greater High Positive
3000572 Hepatitis C Virus (HCV) by Quantitative NAAT Not Detected

Interpretive Data

This panel of tests should not be used for blood donor screening, associated reentry protocols, or for screening human cell, tissues, and cellular and tissue-based products (HCT/P).

Compliance Category

FDA

Note

Order this panel when the patient has had clinical acute hepatitis of unknown origin for less than six months. If results for HBsAg are repeatedly reactive with an index value between 1.00 and 50.00, then HBsAg Confirmation will be added. Additional charges apply. If the anti-HCV screening result is low positive or high positive, the Hepatitis C Virus by Quantitative NAAT will be added. Additional charges apply.

Hotline History

N/A

CPT Codes

80074; if reflexed, add 87341, and 87522

Components

Component Test Code* Component Chart Name LOINC
0020089 Hepatitis B Surface Antigen 5196-1
0020092 Hepatitis B Core Antibody, IgM 24113-3
0020093 Hepatitis A Antibody, IgM 13950-1
2002404 Hepatitis C Antibody by CIA Index 57006-9
3003010 Hepatitis, Acute Panel w/ Rflx Interp 19146-0
3003128 Hepatitis C Antibody by CIA Interp 13955-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Acute Hep Panel, reflex to confirmation
  • HAV IgM Ab
  • HBsAg confirmation
  • HBV core IgM Ab; HCV Ab
  • Hep Panel reflex to confirmation
  • Hepatitis A Antibody, IgM
  • Hepatitis B Core Antibody, IgM
  • Hepatitis B Surface Antigen
  • Hepatitis C Antibody
  • Hepatitis C Antibody by CIA
  • Hepatitis panel
  • Hepatitis screening panel
  • Hepatitis Screening Profile, Serum
  • Hepatitis, Acute Panel
  • Viral hepatitis panel
Hepatitis Panel, Acute with Reflex to HBsAg Confirmation and Reflex to HCV by Quantitative NAAT